pH, 药物浓度和表面活性剂对盐酸二氢埃托啡透皮作用的影响

pH, 药物浓度和表面活性剂对盐酸二氢埃托啡透皮作用的影响

陈小平, 郭庆东, 石庭森

北京军事医学科学院, 北京 100850

收稿日期:1994-11-22 修回日期:1995-05-15 出版日期:1995-12-15 发布日期:1995-12-15

Transdermal Permeation of Dihydro Etorphine Hydro-chloride-Influence of pH, Concentration and Surfactants on in vitro Permeation

Xiao-Ping Chen, Qing-Dong Guo, Ting-Sen Shi

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

Received:1994-11-22 Revised:1995-05-15 Online:1995-12-15 Published:1995-12-15

摘要/Abstract

摘要： 利用大鼠离体皮肤, 对二氢埃托啡(DHE)的体外透皮进行了研究, 结果当pH为5, 3, 7, 9时在其它条件相同的情况下, DHE的透过速率按顺序增加; DHE浓度对透皮速率影响较为复杂, 当pH为7和9时, DHE浓度分别为20, 40, 80 μg/ml时, 透皮速率常数与浓度无关, 当pH为3和5时, 透皮速率常数与浓度有一定的相关性; 一些透皮促渗剂的影响为: 50%乙醇无促进作用, 10% 1,2-丙二醇促进作用甚微, 3%氮酮使DHE透皮速率提高到1.95倍, 3%薄荷醇使DHE透皮速率提高到4.86倍。

关键词: 透皮吸收, 二氢埃托啡, Wistar大鼠, 氮酮, 薄荷醇

Abstract: Effects of pH , donor phase concentration and surfactants on skin permeation in vitro were investigated using excised rat skin. Percutaneous absorption rate of dihydro etorphine hydrochloride(DHE) was increased in the of pH 5, pH 3, pH 7 and pH 9. When the DHE concentration was from 20 to 80 μg/ml, the permeation rate at different concentrations was ratherstable at pH 7 and 9, but was intricated at pH 3 and 5.Skin penneation treated with1, propanediol, Azone, and 3% menthol in 50% ethanol solution increased the permeability of DHE by 1.16, 1.95, 4.86 times , respectively.

Key words: Percutaneous absorption, Dihydro etorphine hydrochloride, Wistar rat, Azone, Menthol

Supporting:

陈小平, 郭庆东, 石庭森. pH, 药物浓度和表面活性剂对盐酸二氢埃托啡透皮作用的影响[J]. .

Xiao-Ping Chen, Qing-Dong Guo, Ting-Sen Shi. Transdermal Permeation of Dihydro Etorphine Hydro-chloride-Influence of pH, Concentration and Surfactants on in vitro Permeation[J]. .

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