去甲米利酮对豚鼠乳头肌慢反应动作电位和细胞内cAMP水平的影响

去甲米利酮对豚鼠乳头肌慢反应动作电位和细胞内cAMP水平的影响

张殿增, 赵更生, 付杰民

1. 西安医科大学药理教研室, 西安 710061;
2. 重庆医药工业研究所药理室, 重庆 630061

收稿日期:1992-10-08 修回日期:1993-10-07 出版日期:1994-06-15 发布日期:1994-06-15

Effects of Dismerinoneon High K+ Depolarized Slow Response Action Potentials and Intracellular cAMP Levelin Guinea Pig Papillary Muscles

Dian-Zeng Zhang, Geng-Sheng Zhao, Jie-Min Fu

1. Department of pharmacology, Xian Medical University, Xian 710061;
2. Department of pharmacology, Chongqing Institute of Medicinal Industry, Chongqing 630061

Received:1992-10-08 Revised:1993-10-07 Online:1994-06-15 Published:1994-06-15

摘要/Abstract

摘要： 在豚鼠乳头肌上观察了米利酮的衍生物去甲米利酮(DMR)对高K⁺除极引导的慢反应动作电位及其cAMP含量的影响。在高K⁺除极的豚鼠心乳头肌标本上, DMR诱发出了慢反应动作电位, 并增加其APA, Vmax和APD50, 呈剂量依赖关系。同时, DMR使同一标本上的cAMP含量明显增加。结果与异丙肾上腺相似。但β-肾上腺素能受体阻滞剂普萘洛尔对DMR的作用无明显影响。说明DMR的作用与β-受体无关。

关键词: 去甲米利酮, 慢反应动作电位, cAMP

Key words: Dismerinone, Slow response action potentials, cAMP

Supporting:

张殿增, 赵更生, 付杰民. 去甲米利酮对豚鼠乳头肌慢反应动作电位和细胞内cAMP水平的影响[J]. .

Dian-Zeng Zhang, Geng-Sheng Zhao, Jie-Min Fu. Effects of Dismerinoneon High K+ Depolarized Slow Response Action Potentials and Intracellular cAMP Levelin Guinea Pig Papillary Muscles[J]. .