葫芦素B对小鼠的免疫增强作用

葫芦素B对小鼠的免疫增强作用

刘颖菊, 刘文清

重庆医科大学药理学教研室重庆 630046

收稿日期:1992-09-11 修回日期:1993-05-29 出版日期:1993-12-15 发布日期:1993-12-15

Immunopotentiating Effects of Cucurbitacin B in Mice

Ying-Ju Liu, Wen-Qing Liu

Department of Pharmacology; Chongqing University of Medical Sciences; Chongqing 630046

Received:1992-09-11 Revised:1993-05-29 Online:1993-12-15 Published:1993-12-15

摘要/Abstract

摘要： 葫芦素 B(CuB) 是中药甜瓜蒂的主要成分, 为四环三萜类物质。葫芦素 B 0.1 mg/kg 即能提高小鼠外周血液 T 淋巴细胞数; 0.2 mg/kg 能提高 PHA 诱导的 T 淋巴细胞转化率和脾脏空斑形成细胞数; 0.4 mg/kg 时血清溶血素水平也明显增加。较大剂量(0.8 mg/kg)时碳粒廓清率及腹腔巨噬细胞吞噬率显著提高。结果表明:葫芦素 B 能增强整个免疫系统功能, 对细胞免疫的作用最强, 对体液免疫也有较强作用。

关键词: 葫芦素B, 巨噬细胞, 溶血素, 空斑形成细胞, 淋巴细胞转化, T 淋巴细胞

Abstract: Cucurbitacin B (CUB) is a major active principle contained in the calyx melo of Cucumis melo L. The immunopotentiating effects of CuB (im, qd×5) were studied.At lower doses, CuB increased the number of peripheral blood T lymphocytes (0.1 mg/kg), the rate of PHA-induced lymphocyte transformation (0.2 mg/kg), the number of plaque forming cells(PFC)of the spleen(0.2 mg/kg) and the level of serum hemolysin (0.4 mg/kg). The phagocytosis of macrophages and the clearance rate of charcoal particles were enhanced only by a large dose(0.8 mg/kg). The results indicate that CuB can potentiate both cellular and humoral immune function.

Key words: Cucurbitacin B, Macrophage, Hemolysin, Plaque forming cell, Lymphocyte transformation, T lymphocyte

Supporting:

刘颖菊, 刘文清. 葫芦素B对小鼠的免疫增强作用[J]. .

Ying-Ju Liu, Wen-Qing Liu . Immunopotentiating Effects of Cucurbitacin B in Mice[J]. .

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