氟灭酸和甲灭酸对实验性兔色素膜炎的抑制作用

氟灭酸和甲灭酸对实验性兔色素膜炎的抑制作用

申竹芳, George C.Y.Chiou

1. 中国医学科学院药物研究所, 北京 100050;
2. 得克萨斯A&M大学眼科药理研究所, 美国得克萨斯 77843

收稿日期:1992-04-11 修回日期:1993-02-19 出版日期:1993-06-15 发布日期:1993-06-15

Inhibitory Effects of Flufenamic Acid and Mefenamic Acid on Experimental Uveitis in Rabbits

Zhu-Fang Shen, George C.Y.Chiou

1. Institute of Materia Medica Chinese Acadena of Medical Sciences Beijing 100050.China
2. Institute of Ocular Pharmacology, Texay A & M University College.Station, Texas 77843 USA

Received:1992-04-11 Revised:1993-02-19 Online:1993-06-15 Published:1993-06-15

摘要/Abstract

摘要： 实验性兔色素膜炎是用兔晶状体蛋白液注入眼前房所引起。用特殊的萤光光度计客观测定眼前房萤光素的水平以表示炎症的程度。当静脉注射氟灭酸和甲灭酸时, 眼炎症的抑制作用显现出量关系。氟灭酸剂量为5.0, 12.5, 25.0 mg/kg 时, 能把时效曲线下方的面积降至对照组的22.3%, 11.5%, 9.3%; 而甲灭酸在剂量为6.2.12.5, 25.0 mg/kg 时, 可把曲线下方的面积降至对照组的35.5%, 21.0%, 8.6%。眼滴注1%(W/V)氟灭酸或甲灭酸眼药水50 μl, 给药眼及对侧眼内的萤光素水平均下降, 给药眼曲线下方的面积降至20.3%, 对侧眼降至50%左右。结果表明, 氟灭酸和甲灭酸不论在静脉注射或眼滴注情况下, 均能抑制眼炎症。

关键词: 氟灭酸, 甲灭酸, 兔色素膜炎

Abstract: The experimental uveitis was induced by injecting lens protein into the antertor cham- ber of rabbit's eye. A special fluorophotometer was used for objectively measuring the flaoreseein level in the anterior chamber of the eve to rellect the degree of inflammation. When administered intravenously. The inhibitory effects of flufenamic acid and mefenamic acid on experimental uveius showed a dose-dependent relationship, The former at dosages 5.0.12.5 and 250 mg kg decreased the areas under the time-response curve to 22.3%.11.5% and 9.3% of the control, respectively: however the latter at dosages 6.2.12.5 and 25.0 mg/kg decreased the areas under the curve to 35.5%.21.0% and 8.6% of the control, respectively. When instilled by ocular route.50μl of 1% eye-drops of flufenmic acid or mefenamic acid lowered the fluoreseein levels of treated eyes as well as contra-lateral eyes. The areas under the time-response curve for treated eyes were decreased to 20.3% of the control and those of contra-lateral eyes to about 50% of the control. The results indicate that both flufenamic and mefenamic acids, applied intravenously or topically, can inhibit ocular inflammation.

Key words: Flufenamic acid, Mefenamic acid, Ocular inflammation

Supporting:

申竹芳, George C.Y.Chiou. 氟灭酸和甲灭酸对实验性兔色素膜炎的抑制作用[J]. .

Zhu-Fang Shen, George C.Y.Chiou. Inhibitory Effects of Flufenamic Acid and Mefenamic Acid on Experimental Uveitis in Rabbits[J]. .