抗病毒药物的发现及进展

doi:10.5246/jcps.2010.06.056

摘要/Abstract

摘要：

本篇综述讨论了多种类型的抗病毒药物及其治疗前景, 主要是针对于HIV病毒。这些药物作用于病毒感染的整个过程, 包括病毒的进入、复制及释放。这对于联合治疗是非常重要的, 联合治疗一般至少由3种药物组成, 现在已经成为治疗AIDS的标准。

Abstract:

In this short review we summarize the different strategies for discovery and development of antiviral agents, including targeting virus entry into host, virus replication within cells, infant virus assembly and release from the infected cells. The progress on development of various classes of antivirus agents and their potential in virus therapy, mainly targeting human immunodeﬁciency virus (HIV), was also discussed.

Key words: Antivirals, Vaccine, Virus replication, Virus entry, Virus release

中图分类号:

R915

Supporting:

Foundation items: National Basic Research Program of China (973 Program, Grant No. 2010CB-12300), National Natural Science Foundation of China (Grant No. 20932001 and 20852001) and "985" Project Foundation (Grant No. 985-2-126-121).

^*Corresponding author. Tel./fax: 86-10-82805519

张镇, 王涵, 杜凌燕, 陈昆勃, 肖苏龙, 俞飞, 张礼和, 周德敏^*. 抗病毒药物的发现及进展[J]. , DOI: 10.5246/jcps.2010.06.056.

Zhen Zhang, Han Wang, Ling-Yan Du, Kun-Bo Chen, Su-Long Xiao, Fei Yu, Li-He Zhang, De-Min Zhou^*. Discovery and development of antiviral drugs [J]. , DOI: 10.5246/jcps.2010.06.056.

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