Journal of Chinese Pharmaceutical Sciences

Structure Determination of Inflasaponin II and VI from Glycyrrhiza inflata Root

Kun Zou, Yu-Ying Zhao, Ru-Yi Zhang

1995, 4(3): 113-117.

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Seven triterpenoid saponins were isolated from the 10% EtOH extract of the root of Glycyrrhiza nflata Bat. On the basis of chemical and spectroscopic methods, two of them were identified as glycyrrhetic acid-3-O-β-D-6''-ethyl-glucuronopyranosyl-(1→2)-β-D-6' -n-butyl-glucuro-nopyranoside(1), and lycyrrhetic acid-3-O-β-D-6''-n-butyl-glucuronopyranosyl-(1→2)-β-D-6'-n-ethyl-glucuronopyranoside(2). Both are new compounds and named inflasaponins Ⅱ and Ⅵ respectively.

A Study in vitro on the Synergetic Cytocidal Effect of Ascorbic Acid and Mitomycin C against the Ehrlich As-cites Tumor Cells in Culture

Xi Min, Pan-Hai Li, Yi-Hui Pang

1995, 4(3): 118-124.

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The synergetic cytocidal effect of ascorbic acid and mitomycin C on Ehrlich as-cites tumor cells in culture was studied. The chain scission of DNA by Cu(II) mitomycin C/ascorbic acid system, and the chemical kinetics of the Cu(II) catalyzed aerobic oxidation of ascorbic acid in the presence of mitomycin C were also discussed. Experimental results showed that ascorbic acid and mitomycin C were synergetic in destroying Ehrlich ascites tumor cells.The effect is related to the breaking action of the Cu(II) mitomycin C/ascorbic acid system on the DNA chain, and to the quantity of the system produced ·OH, and the speed of production which are both directly proportional to the concentration of ascorbic aci.These results imply that the ·OH produced in the aerobic oxidation of ascorbic acid, and·OH induced scission of DNA chain, are important factors to he synergetic cytocidal effect of ascorbic acid and mitomycin C on Ehrlich ascites tumor cells.

A Simplified Expression for a Diffusion-Dissolution Controlled Release of Drug from Matrix in TDDS

Jun-Min Zheng, Li Yang, You-Qing He

1995, 4(3): 125-130.

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Chandrasekran-paul (1982)对药物由骨架系统中的释放, 提出下列表达式:

本文在常见的实验时间及适当的K值范围内对上式作了简化, 药物释放的累积量与时间的平方根直接成比例, 但方程中带有一截距项, 即

, 硝苯地平贴剂及普萘洛尔贴剂二者的释放行为都符合上述方程, 其相关系数良好。氢化可的松乳膏的释放数据(据Shah, 1989), 也可用相同的方程来描述。该方程与Higuchi方程相比较, 多出一个截距项, 这可能与药物溶出特性有关。

Inhibiting Effect of Lobenzarit Disodium on the Inter-leukin-1 Activity in Normal and in Adjuvant ArthritisKats and on the H2O2 Release from Rat Peritoneal Macro-phages

Wei-Dong Li, Zhi-Bin Lin

1995, 4(3): 131-135.

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The effects of Lobenzarit disodium (CCA) upon the activity of interleukin-1(IL-1) of peritoneal macrophages (PMΦ) in normal and in adjuvant arthritis AA) rats and on the release of hydrogen peroxide (H2O2) of rat peritoneal macrophages were studied. CCA 10~200 μg/mL could inhibit IL-1activity in normal rat in vitro; CCA 10 and 50 mg/kg could depress the level of increased IL-1 in AA rats in vivo; CCA 5~100 μg/mL could inhibit the release of H2O2 from rat PMΦ in vitro. The results suggest that these effects could be one of the mechanisms of anti-inflammatory action of CCA.

A Study of Interaction of Cisplatin and Its Analogues withPhospholipid of Erythrocyte Membrane

Jing-Fen Lu, Wen-Sheng Xia, Kui Wang, Chun Zhai, Qing-Liang Liu

1995, 4(3): 136-143.

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The interaction of cisplatin and its analogues with phospholipid molecules of human erythrocyte membranes was studied using IR and ³¹P NMR methods. Dramatic changes were ob-served at 1300~953 cm^-1 frequency region on the IR spectra .Based on the IR data analysis, it was speculated that the Pt(II) complexes interacted mainly with the polar head groups of phospholipids through electrostatic interaction and certain coordination patterns. The 12 h dynamic experiment showed that a recoverable process occurred in case of cis-DCDP and an unrecoverable one for other Pt(II) analogues.A similar conclusion could be obtained from ³¹P NMR experimental results. The diversity was discussed.

Effects of Rhynchophylline on Guinea Pig Atria

Chang-Xun Chen, Ruo-Min Jin, Qun Wang, Hai-Gui Zhang

1995, 4(3): 144-148.

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Fluorescence Study on The Interaction Between Cisplatin and Erythrocyte Membrane Proteins

Bao-Wei Chen, Kui Wang

1995, 4(3): 149-153.

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The interaction between cisplatin and erythrocyte membrane proteins was studied based on the quenching effect of cisplatin on the intrinsic fluorescence of proteins. A concentration-dependent quenching effect was observed. The presence of chloride and sulphate weakens the effect significantly. A pH-dependence was also noted with a stronger effect in acidic solution. The nature of the interaction is considered to be platinum-thiol group binding according to the effect of cisplatin on the fluorescence of FMA labeled membrane. The mechanism of the cisplatin-protein interactions was discussed based on the effect of coexisting anion.

The Alkaloid Constituents in the Seeds of Sophora Viciifo-lia

Xiu-Kun Wang, Jia-Shi Li, Shigeru Omiya, Lu-Xue Wei

1995, 4(3): 154-156.

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Chemical Constituents of Rubia yunnanensis Root

Xiao-Ying Xu, Jin-Yun Zhou, Qi-Cheng Fang

1995, 4(3): 157-160.

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