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Jun-Min Zheng, Li Yang, You-Qing He
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Abstract: Chandrasekran-paul (1982)对药物由骨架系统中的释放, 提出下列表达式: 本文在常见的实验时间及适当的K值范围内对上式作了简化, 药物释放的累积量与时间的平方根直接成比例, 但方程中带有一截距项, 即, 硝苯地平贴剂及普萘洛尔贴剂二者的释放行为都符合上述方程, 其相关系数良好。氢化可的松乳膏的释放数据(据Shah, 1989), 也可用相同的方程来描述。该方程与Higuchi方程相比较, 多出一个截距项, 这可能与药物溶出特性有关。
Key words: Higuchi's equation, Chandrasekran-paul's equation, Drug release from matrix in TDDS
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Jun-Min Zheng, Li Yang, You-Qing He . A Simplified Expression for a Diffusion-Dissolution Controlled Release of Drug from Matrix in TDDS[J]. .
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URL: http://jcps.bjmu.edu.cn/EN/
http://jcps.bjmu.edu.cn/EN/Y1995/V4/I3/125
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