Abstract: The effects of Lobenzarit disodium (CCA) upon the activity of interleukin-1(IL-1) of peritoneal macrophages (PMΦ) in normal and in adjuvant arthritis AA) rats and on the release of hydrogen peroxide (H2O2) of rat peritoneal macrophages were studied. CCA 10~200 μg/mL could inhibit IL-1activity in normal rat in vitro; CCA 10 and 50 mg/kg could depress the level of increased IL-1 in AA rats in vivo; CCA 5~100 μg/mL could inhibit the release of H2O2 from rat PMΦ in vitro. The results suggest that these effects could be one of the mechanisms of anti-inflammatory action of CCA.

Key words: Lobenzarit disodium, Interleukin-1, Hydrogen peroxide, Peritoneal macrophage, Anti-inflammatory effect