Abstract: The interaction of cisplatin and its analogues with phospholipid molecules of human erythrocyte membranes was studied using IR and ³¹P NMR methods. Dramatic changes were ob-served at 1300~953 cm^-1 frequency region on the IR spectra .Based on the IR data analysis, it was speculated that the Pt(II) complexes interacted mainly with the polar head groups of phospholipids through electrostatic interaction and certain coordination patterns. The 12 h dynamic experiment showed that a recoverable process occurred in case of cis-DCDP and an unrecoverable one for other Pt(II) analogues.A similar conclusion could be obtained from ³¹P NMR experimental results. The diversity was discussed.

Key words: Cisplatin, Membrane phospholipid, 31P NMR, IR