Oseltamivir decorated gold nanorods for visible rapid detection of influenza virus

doi:10.5246/jcps.2022.07.042

Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (7): 491-498.DOI: 10.5246/jcps.2022.07.042

• Original articles • Next Articles

Oseltamivir decorated gold nanorods for visible rapid detection of influenza virus

Wenbin Liu¹, Dong Liu¹, Xue Wang¹, Zhaoliang Yang², Yun He³, Yang Yang¹^,^*()

1 College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
2 Axsyn (Tianjin) Biotechnology Co., Ltd., Tianjin 300457, China
3 Anxuyuan Biotechnology (Shenzhen) Co., Ltd., Shenzhen 518052, Guangdong, China

Received:2021-07-30 Revised:2021-08-10 Accepted:2021-12-14 Online:2022-07-31 Published:2022-07-31
Contact: Yang Yang

Abstract

Abstract:

In the present study, we developed a novel colorimetric strategy for the visible rapid detection of the influenza virus based on the unique optical properties of gold nanorods. Specifically, lipoic acid-modified Oseltamivir (OS), which is a strong neuraminidase inhibitor and used as the first-line drug in the treatment of influenza, was synthesized and further attached to the surface of gold nanorods (OS-LA-GNRs). The absorption band and density of OS-LA-GNRs were changed with the decreasing distance between the nanoparticles induced by the target-specific aggregation via strong neuraminidase–OS binding. All of these could be visible with the naked eyes and measured by UV-visible spectrophotometry. The results showed that our system had a comparable limit of detection (LOD) to the commercial colloidal gold stripes, making it feasible for wide diagnostic applications.

Key words: Gold nanorods, Oseltamivir, Influenza virus, Neuraminidase, Visible detection

Supporting:

Wenbin Liu, Dong Liu, Xue Wang, Zhaoliang Yang, Yun He, Yang Yang. Oseltamivir decorated gold nanorods for visible rapid detection of influenza virus[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(7): 491-498.

Figures/Tables 3

References 21

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Oseltamivir decorated gold nanorods for visible rapid detection of influenza virus

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