Effect of Nrf2 on the testicular microenvironment and its research progress in male diseases

doi:10.5246/jcps.2023.07.043

Abstract

Abstract:

Oxidative stress (OS) is an imbalanced state between the production of reactive oxygen species (ROS) and antioxidation, and plays a crucial role in the development and progression of various diseases. Nrf2, a major regulator of ROS production and restoration of redox balance, exerts significant regulatory effects on the body and cells. For example, by regulating the testis microenvironment, Nrf2 can improve oxidative damage to Leydig, Sertoli, and spermatogenic cells, thus affecting testosterone synthesis and protecting male reproductive health. Moreover, Nrf2 is crucial in regulating late-onset hypogonadism in males and male infertility. Nrf2 is also involved in the pathogenesis of many other male diseases, such as benign prostatic hyperplasia, prostate cancer, prostatitis, erectile dysfunction, and varicocele. Therefore, Nrf2 could be a promising target for treating and preventing male diseases, and it holds great potential in clinical practice.

Key words: Nrf2, Testicular microenvironment, Male disease, Research progress

Supporting:

Hui Wu, Gang Ning, Bonan Li, Xing Zhou. Effect of Nrf2 on the testicular microenvironment and its research progress in male diseases[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(7): 513-526.

Figures/Tables 2

References 98

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