Table of Content

15 December 1995, Volume 4 Issue 4

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Full Papers

Triterpenoid Saponins from the Bark of Nothopanax davidii

Shi-Shan Yu, De-Quan Yu^*, Xiao-Tian Liang

1995, 4(4):  167-176. 

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Two new triterpenoid saponins named yiyeliangwanoside VII [1] and VIII [2], along with a known triterpenoid saponin liangwanoside II [3] were isolated from the alcoholic extract of the bark of Nothopanax davldii (Franch.) Harms (family Araliaceae). Their structures have been determined on the basis of spectral and chemical data as 3-O-β-(2',4'-O-diacetyl)-D-Xylopyrano-syl-3β-hydroxyolean-12-ene-28, 29-dioic acid-28-O-[α-rhamnopyranosyl (1-4)-β-D-glucopyano-syl (1-6)-β-D-glucopyranosyl] ester [1]; 3-O-β-(3'-O-acetyl)-D-xylopyranosyl-3β-hydroxyolean-12-ene-28,29-dioic acid-28-O-[α-L-rhamnopyranosyl (1-4)-β-D-glucopyranosyl (1-6)-β-D-glu-copyranosyl] ester [2]; 3-O-α-L-arabinopyranosyl-3β-hydroxyolean-12-ene-28, 29-dioic acid-28-O-[α -L-thamnopyranosyl (1-4)-β-D-glucopyranosyl (1-6)-β-D-glucopyranosyl] ester [3].

SOD-like Activities of SOD and Cu(II) Complexes in Liposomes

Yan Liu, Lian-Tao Li, Jing Sun, Chun-Su Lu

1995, 4(4):  177-180. 

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The SOD-like activities of SOD, four Cu(II) Complexes, SOD-and Cu(II) com-plex-liposomes were determined respectively by using cytochrome C method. The results showed that all of these systems had SOD-like activities to some extent of which the Cu(His)2-liposome displayed the highest activity and the Cu(II) complexes and liposomes had some positive cooperative action.

Targeting Effect Studyof 3H-Mitoxantrone Nanosphereson Hepatocellular Carcinoma (HCC) Modelin Nude Mice

Zhi-Rong Zhang, Gong-Tie Liao, Shi-Xiang Hou

1995, 4(4):  181-186. 

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The distribution of 3H-mitoxantrone polybutyl cyanoacrylate nanospheres 3H-DHAQ-PBCA-NS)in the viscera, muscle and tumors of human hepatocellular carcinoma (HCC)model in nude mice was studied with liquid scintillation counting techniique. The results showed that the 3H-DHAQ-PBCA-NS had remarkable liver targeting effect. The content of 3H-DHAQ-PBCA-NSin liver and heterotopic liver tumor was found to be 71.31±10.49% of total amount of drug in animal body. It was also found that the content of 3H-DHAQ-PBCA-NS in liver was higher than that in liver tissue, and the content of 3H-DHAQ-PBCA-NS in annpit tumor was higher than that in armpit muscle tissue, but had no significant difference; It provides an ideal preparation for the DHAQ admini-stration.

Transdermal Permeation of Dihydro Etorphine Hydro-chloride-Influence of pH, Concentration and Surfactants on in vitro Permeation

Xiao-Ping Chen, Qing-Dong Guo, Ting-Sen Shi

1995, 4(4):  187-192. 

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Effects of pH , donor phase concentration and surfactants on skin permeation in vitro were investigated using excised rat skin. Percutaneous absorption rate of dihydro etorphine hydrochloride(DHE) was increased in the of pH 5, pH 3, pH 7 and pH 9. When the DHE concentration was from 20 to 80 μg/ml, the permeation rate at different concentrations was ratherstable at pH 7 and 9, but was intricated at pH 3 and 5.Skin penneation treated with1, propanediol, Azone, and 3% menthol in 50% ethanol solution increased the permeability of DHE by 1.16, 1.95, 4.86 times , respectively.

Changes of Monoanine Levelsin Different Brain Regionsof Rat with Ventral Giobus Pailidus Injuredby Kainic Acid Injection

Jian-Zheng Zhou, Hua-Jin Dong, Wen Xiao

1995, 4(4):  193-198. 

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Ventral globus pallidus-injured rats by kainic acid(10 mg) were used to derter-mine the monoamine levels in four different brain regions.In this model, a great decrease of NE con-centration was observed in both hippocampus and frontal cortex compared with nonnal contro. This result hints that a damage of noradrenergic neurons in this model has occurred. DA concentrations in the four brain zones after kainic acid injection were all reduced, but only in the frontal cortex and striatum the pronounced reductions were discovered while DA turnover rates in frontal cortex, stria-tum and meddullapons were significantly reduced. These results revealed a DA metabolic disorder occurring in these regions.However, 5-HT concentrations as well as DBH activity, expressed by ratio of NE/DA, showed no marked difference in this model. In our study it is found that the changes of monoamine levels in this model basically reflect those discovered in AD patients.

Pharmacokinetics of Ferulic Acid in Rabbits with Blood Stasis

Ai-Dong Wen, Yong-Pei Jiang, Xi Huang, Ya-Xuan Fan, Lei-Hua Zhang

1995, 4(4):  199-204. 

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To test and study the Syndrome and Treatment Pharmacokinetics (S & TRK), we studied the pharmacokinetics of ferulic acid in healthy and blood stasis (microcirculation dysfunction)rabbits by RP-HPLC. After a single intravenous injection offenilic acid (5 mg/kg) to healthy and blood stasis rabbits, compartment model of ferulic acid serum concentration was fitted and then pharmacokinetic parameters were calculated with a MCPKP program on a COMPAQ 386 compute Important parameters are as follows: In healthy rabbits VB = 0.9525±0.0211 L/kg, V1 = 0.2462±0.0381 L/kg, CLB = 1.8133±0.9512 L/h·kg, T1/2β = 0.3639±0913, AUC = 2.7566±0.8232 μg·h/ml; In blood stasis rabbits VB = 0.7882±0.0321 L/kg, V1 = 0.1966±0.0537 L/kg, CLB = 0.8820±0.5481 L/h·kg, T1/2β = 0.6193±0.1216 h, AUC = 5.6690±2.3541 μg·h/ml.Through this experiment we found the sig-nificant differences in the FA's pharmacokinetic parameters between healthy and blood stasis rabbits.The results obtained correspond with S & TPK.

Uitrastructural Observation on Rat Spermatozoa Treated with Tripchlorolide (T4) from Tripterygium wilfordii

Lian-Kai Dang, Ying Wang, Jing-Fang Dai, Jin-Song Qiu, shu-Lin zhang, Guang-Li Fu, Yi-Bin Sun

1995, 4(4):  205-211. 

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Adult male rats were treated orally with monomer T4 (Tripchlorolide) isolated from Tripterygium wilfordii, at the dose of 50 μg/kg/day, 6 days/week for 6 weeks.Ultrathin section and freeze etching replica of seminiferous tubules and epididymal spermatozoa were examined with elec-tron microscope. The results showed that the spemiogenesis was inhibited T4 in seminiferous tu-bules. However, the damage and disruption of the spermatozoa were more serious in the epididymis.Damage of the structure and function ot microtubule and microfilament may be the chief reason for sperm damage. Sperm membrane was also very sensitive to the treatiment of monomer T4.

Communications

Synthesis and Biological Activity of N-Acetylmuramyl-L-Valyl-D-Glutamic Acid α-n-Butyl Ester

Shou-Ming Wen, Ying Li, Xiong-Qi Gong, Qin-Hui Xu, Kang-Tai Rong

1995, 4(4):  212-216. 

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Antitumor Actinity of Puqietinone, a Novel Alkaloid from the Bulbs of Fritillaria puqiensis

Ping Li, Yi-Xian Wang, Guo-jun Xu, Luo-Shan Xu

1995, 4(4):  217-220. 

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Polymethylenebis [acetamides] Analogues. Synthesis and Differentiation-Inducing Activity on HL-60Cells

Xiao-Xia Wen, Dian-Shun Guo, Zhi-Yong Hu, Hui-Cai Wang

1995, 4(4):  221-224. 

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