Direct identification of volatile compounds in the artificially cultivated and wild Chinese medicinal materials (Semiliquidambar cathayesis) by headspace-gas chromatography-ion mobility spectrometry

doi:10.5246/jcps.2023.05.033

Abstract

Abstract:

Semiliquidambar cathayesis (SC) is often used as traditional Chinese medicine (TCM) in the market, and its wild resources are now severely damaged and on the verge of extinction. In order to preserve and apply SC resources preferably, artificially cultivated SC is generated. In the present study, the variations of volatile organic compounds (VOCs) in the artificially cultivated and wild SC were analyzed by headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) combined with principal component analysis (PCA). The medicinal value of artificially cultivated SC was determined by comparing the differences between these SCs. The results showed that the artificially cultivated and wild SCs had the same composition for the VOCs, and the VOCs in the bark and stem used to adjust the efficacy of liquid medicine in SCs were not significantly different. Collectively, the findings provided a scientific theory for the application of artificially cultivated SC and the replacement of wild SC.

Key words: Semiliquidambar cathayesis, Traditional Chinese medicine, Fingerprint, Volatile organic compounds, Headspace-gas chromatography-ion mobility spectrometry

Supporting:

Yonghui Ge, Ling Wang, Su Xu, Tianli Jiang, Jinhua Wang. Direct identification of volatile compounds in the artificially cultivated and wild Chinese medicinal materials (Semiliquidambar cathayesis) by headspace-gas chromatography-ion mobility spectrometry[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(5): 392-405.

Figures/Tables 6

References 37

[1]	Sun, W.B.; Ma, Y.P.; Blackmore, S. How a new conservation action concept has accelerated plant conservation in China. Trends Plant Sci. 2019, 24, 4–6.
[2]	Yang, L.; Liu, R.H.; He, J.W. Rapid analysis of the chemical compositions in semiliquidambar cathayensis roots by ultra high-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry. Molecules. 2019, 24, E4098.
[3]	Zhang, J.Y.; Kaliaperumal, K.; Liu, Z.Y.; Zhang, J. Chemical constituents from Semiliquidambar chingii and their chemotaxonomic significance. Biochem. Syst. Ecol. 2022, 100, 104360.
[4]	Ye, X.Z.; Liu, D.; Luo, J.J.; Fan, H.H.; Zhang, G.F.; Liu, B.; Chen, S.P. Transcriptome analysis for rare and endangered plants of Semiliquidambar cathayensis. Bulletin Botanical Res. 2019, 39, 276–286.
[5]	Zhang, M.Z.; Jiang, Y.T.; Ye, X.Z.; Chen, S.P.; Fan, H.H.; Liu, B. The complete chloroplast genome of semiliquidambar cathayensis (Hamamelidaceae). Mitochondrial DNA B. 2020, 5, 695–696.
[6]	Wu, W.; Zhou, R.; Huang, Y.; Boufford, D.E.; Shi, S. Molecular evidence for natural intergeneric hybridization between Liquidambar and Altingia. J. Plant Res. 2010, 123, 231–239.
[7]	Ye, X.Z.; Wen, G.W.; Zhang, M.Z.; Liu, Y.P.; Fan, H.H.; Zhang, G.F.; Chen, S.P.; Liu, B. Genetic diversity and genetic structure of a rare and endangered species Semiliquidambar cathayensis Hung T. Chang. Plant Sci. J. 2021, 39, 415–423.
[8]	Huang, L.H.; Chen, Q.T.; Xiao, Y.S.; Miao, S.Y.; Song, L.Y. Optimization and primers screening of ISSR-PCR reaction system for Semiliquidambar cathayensis Chang. Molecular Plant Breeding. 2021, 19, 6782–6789.
[9]	Li, Q.L.; Li, R.Q.; Cao, G.; Wu, X.; Yang, G.M.; Cai, B.C.; Cheng, B.; Mao, W.M. Direct differentiation of herbal medicine for volatile components by a multicapillary column with ion mobility spectrometry method. J. Sep. Sci. 2015, 38, 3205–3208.
[10]	Yuan, Z.Y.; Li, J.; Zhou, X.J.; Wu, M.H.; Li, L.; Pei, G.; Chen, N.H.; Liu, K.L.; Xie, M.Z.; Huang, H.Y. HS-GC-IMS-Based metabonomics study of Baihe Jizihuang Tang in a rat model of chronic unpredictable mild stress. J. Chromatogr. B. 2020, 1148, 122143.
[11]	Zhang, J.; Zhang, W.G.; Zhou, L.; Zhang, R.Y. Study on the influences of ultrasound on the flavor profile of unsmoked bacon and its underlying metabolic mechanism by using HS-GC-IMS. Ultrason. Sonochem. 2021, 80, 105807.
[12]	Cavanna, D.; Zanardi, S.; Dall’Asta, C.; Suman, M. Ion mobility spectrometry coupled to gas chromatography: a rapid tool to assess eggs freshness. Food Chem. 2019, 271, 691–696.
[13]	Wang, S.Q.; Chen, H.T.; Sun, B.G. Recent progress in food flavor analysis using gas chromatography-ion mobility spectrometry (GC-IMS). Food Chem. 2020, 315, 126158.
[14]	Karpas, Z. Applications of ion mobility spectrometry (IMS) in the field of foodomics. Food Res. Int. 2013, 54, 1146–1151.
[15]	Arroyo-Manzanares, N.; Martín-Gómez, A.; Jurado-Campos, N.; Garrido-Delgado, R.; Arce, C.; Arce, L. Target vs spectral fingerprint data analysis of Iberian ham samples for avoiding labelling fraud using headspace-gas chromatography-ion mobility spectrometry. Food Chem. 2018, 246, 65–73.
[16]	Yao, W.S.; Cai, Y.X.; Liu, D.Y.; Chen, Y.; Li, JR; Zhang, M.C.; Chen, N.; Zhang, H. Analysis of flavor formation during production of Dezhou braised chicken using headspace-gas chromatography-ion mobility spec-trometry (HS-GC-IMS). Food Chem. 2022, 370, 130989.
[17]	Li, X.R.; Dong, Y.F.; Jiang, P.F.; Qi, L.B.; Lin, S.Y. Identification of changes in volatile compounds in sea cucumber Apostichopus japonicus during seasonings soaking using HS-GC-IMS. LWT. 2022, 154, 112695.
[18]	Gu, S.; Zhang, J.; Wang, J.; Wang, X.Y.; Du, D.D. Recent development of HS-GC-IMS technology in rapid and non-destructive detection of quality and contamination in agri-food products. Trac-Trend. Anal. Chem. 2021, 144, 116435.
[19]	Yuan, Z.Y.; Qu, H.Y.; Xie, M.Z.; Zeng, G.; Huang, H.Y.; Ren, F.; Chen, N.H. Direct authentication of three Chinese materia medica species of the Lilii Bulbus family in terms of volatile components by headspace-gas chromatography-ion mobility spectrometry. Anal. Methods. 2019, 11, 530–536.
[20]	Lv, W.S.; Lin, T.; Ren, Z.Y.; Jiang, Y.Q.; Zhang, J.; Bi, F.J.; Gu, L.H.; Hou, H.C.; He, J.N. Rapid discrimination of Citrus reticulata ‘Chachi’ by headspace-gas chromatography-ion mobility spectrometry fingerprints combined with principal component analysis. Food Res. Int. 2020, 131, 108985.
[21]	He, J.; Ye, L.H.; Li, J.H.; Huang, W.K.; Huo, Y.J.; Gao, J.X.; Liu, L.; Zhang, W.T. Identification of Ophiopogonis Radix from different producing areas by headspace-gas chromatography-ion mobility spectrometry analysis. J. Food Biochem. 2021, 00, e13850.
[22]	Guo, S.; Zhao, X.Y.; Ma, Y.; Wang, Y.B.; Wang, D. Fingerprints and changes analysis of volatile compounds in fresh-cut yam during yellowing process by using HS-GC-IMS. Food Chem. 2022, 369, 130939.
[23]	Yin, J.X.; Wu, M.F.; Lin, R.M.; Li, X.; Ding, H.; Han, L.F.; Yang, W.Z.; Song, X.B.; Li, W.L.; Qu, H.B.; Yu, H.S.; Li, Z. Application and development trends of gas chromatography–ion mobility spectrometry for traditional Chinese medicine, clinical, food and environmental analysis. Microchem. J. 2021, 168, 106527.
[24]	Cao, G.; Shou, Q.Y.; Li, Q.L.; Jiang, J.P.; Chen, X.C. Static headspace-multicapillary column with gas chromatography coupled to ion mobility spectrometry as a simple approach for the discrimination of crude and processed traditional Chinese medicines. J. Sep. Sci. 2014, 37, 3090–3093.
[25]	Yin, J.; Lin, R.; Wu, M.; Ding, H.; Han, L.; Yang, W.; Song, X.; Li, W.; Qu, H.; Yu, H.; Li, Z. Strategy for the multi-component characterization and quality evaluation of volatile organic components in Kaixin San by correlating the analysis by headspace gas chromatography/ion mobility spectrometry and headspace gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2021, 35, e9174.
[26]	Leng, P.; Hu, H.W.; Cui, A.H.; Tang, H.J.; Liu, Y.G. HS-GC-IMS with PCA to analyze volatile flavor compounds of honey peach packaged with different preservation methods during storage. LWT. 2021, 149, 111963.
[27]	Gerhardt, N.; Birkenmeier, M.; Sanders, D.; Rohn, S.; Weller, P. Resolution-optimized headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) for non-targeted olive oil profiling. Anal. Bioanal. Chem. 2017, 409, 3933–3942.
[28]	Yang, Y.; Wang, B.; Fu, Y.; Shi, Y.G.; Chen, F.L.; Guan, H.N.; Liu, L.L.; Zhang, C.Y.; Zhu, P.Y.; Liu, Y.; Zhang, N. HS-GC-IMS with PCA to analyze volatile flavor compounds across different production stages of fermented soybean whey tofu. Food Chem. 2021, 346, 128880.
[29]	Zhang, K.Y.; Zhang, C.; Zhuang, H.N.; Liu, Y.; Feng, T.; Nie, B. Characterization of volatile component changes in peas under different treatments by GC-IMS and GC-MS. J. Food Qual. 2021, 2021, 6533083.
[30]	Qiao, Y.N.; Bi, J.F.; Chen, Q.Q.; Wu, X.Y.; Gou, M.; Hou, H.N.; Jin, X.W.; Purcaro, G. Volatile profile characterization of winter jujube from different regions via HS-SPME-GC/MS and GC-IMS. J. Food Qual. 2021, 2021, 9958414.
[31]	Li, M.Q.; Yang, R.W.; Zhang, H.; Wang, S.L.; Chen, D.; Lin, S.Y. Development of a flavor fingerprint by HS-GC-IMS with PCA for volatile compounds of Tricholoma matsutake Singer. Food Chem. 2019, 290, 32–39.
[32]	Xie, S.Y.; Yao, K.L.; Wu, X.J.; Lin, X.G.; Han, C.L.; Ling, F.X.; Lian, H.M. Overview of pharmacological research on Semiliquidambar cathayensis H. T. Chang. J. Fujian Forestry Sci. Technol. 2018, 45, 122–127.
[33]	da Silva Vale, A.; de Melo Pereira, G.V.; de Carvalho Neto, D.P.; Rodrigues, C.; Pagnoncelli, M.G.B.; Soccol, C.R. Effect of co-inoculation with pichia fermentans and pediococcus acidilactici on metabolite produced during fermentation and volatile composition of coffee beans. Fermentation. 2019, 5, 67.
[34]	Wang, H.W.; Zhang, X.; Suo, H.Y.; Zhao, X.; Kan, J.Q. Aroma and flavor characteristics of commercial Chinese traditional bacon from different geographical regions. J. Sens. Stud. 2019, 34, e12475.
[35]	Gao, C.; Wang, R.; Zhang, F.; Sun, Z.C.; Meng, X.H. The process monitors of probiotic fermented sour cherry juice based on the HS-GC-IMS. Microchem. J. 2022, 180, 107537.
[36]	Moiseenko, K.V.; Glazunova, O.A.; Savinova, O.S.; Ajibade, B.O.; Ijabadeniyi, O.A.; Fedorova, T.V. Analytical characterization of the widely consumed commercialized fermented beverages from Russia (kefir and ryazhenka) and South Africa (amasi and mahewu): potential functional properties and profiles of volatile organic compounds. Foods Basel Switz. 2021, 10, 3082.
[37]	Feng, X.Y.; Wang, H.W.; Wang, Z.R.; Huang, P.M.; Kan, J.Q. Discrimination and characterization of the volatile organic compounds in eight kinds of huajiao with geographical indication of China using electronic nose, HS-GC-IMS and HS-SPME-GC-MS. Food Chem. 2022, 375, 131671.