Conformation and Antitumor Activity of Novel Metal Complexes of Piperazinedithioformates

Abstract

Abstract:

The in vitro antitumour efficacy of some novel metal complexes of piperazinedithioformates (SR-M) was examined in six cancer cell lines. The activity was compared with that of piperazinedithioformates. Biological evaluations of a series of SR-M compounds suggest that the compounds 1c (SR-Cu) and 1f (SR-Sn) show a potent antitumor activity. The stable conformation structure of SR-Cu as a representative of SR-M was investigated and confirmed by computer workshop.

Key words: Dithiocarbamates DTC, Dithiocarbamates DTC, antitumor drugs, antitumor drugs, Cu, Cu

CLC Number:

R916.696

R965

Supporting:

HE Fei, HUANG Hui, YIN Fu-ling, LI Run-tao, LEI Xiao-ping, ZENG Hui-hui ^*. Conformation and Antitumor Activity of Novel Metal Complexes of Piperazinedithioformates[J]. .

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Conformation and Antitumor Activity of Novel Metal Complexes of Piperazinedithioformates

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