Bergenin: a versatile and readily available precursor for bioactive modifications

doi:10.5246/jcps.2023.05.029

Abstract

Abstract:

Bergenin, as a major bioactive ingredient of traditional Chinese medicine bergenia, can be found to be a significant component or a secondary metabolite in many families. Bergenin and its derivatives have aroused great interest because their unique bioactivities and pharmacological properties have been gradually disclosed over the past decades. A great number of bergenin derivatives have been synthesized, and their biological activities have been surveyed to achieve many satisfactory results in recent several years. These studies are beneficial in discovering and identifying novel candidates from bergenin derivatives as potential therapeutic drugs and help us understand their molecular targets and mechanisms of pharmacological action. This present work compiled scattered information on semisynthetic derivatives of bergenin and highlighted their recent advances in bioactive modifications.

Key words: Bergenin, Bergenin derivatives, Natural active ingredients, Versatile precursors, Structural modifications

Supporting:

Suqian Cai, Kefeng Zhang, Xiaohua Cai. Bergenin: a versatile and readily available precursor for bioactive modifications[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(5): 333-350.

Figures/Tables 19

Table 1. Bergenin derivatives as inflammatory mediators NO and TNF-α.

Table 2. IC50 values for compounds against DU-145, A549, HCT 116, HepG2, and HeLa cell lines.

Table 3. Antiproliferative activity of compounds against PC-3, SGC-7901, A549, MCF-7, and HepG2 cell lines in vitro.

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