Two terpenoids and a polyketide from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum

doi:10.5246/jcps.2014.06.056

Journal of Chinese Pharmaceutical Sciences ›› 2014, Vol. 23 ›› Issue (6): 421-424.DOI: 10.5246/jcps.2014.06.056

• Original articles • Previous Articles Next Articles

Two terpenoids and a polyketide from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum

Min Zhang^1,2, Ning Li^1,2, Ridao Chen², Jianhua Zou², Chunmei Wang¹, Jungui Dai^1,2*

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received:2014-04-07 Revised:2014-05-05 Online:2014-06-28 Published:2014-05-20
Contact: Tel.: 86-10-63165195
Supported by:
Science & Technology Project of Guangdong Province (Grant No. 2011A080403020) and the Fundamental Research Funds for the Central Universities (Grant No. 2012N06).

Abstract

Abstract:

Three known compounds were isolated from the endophytic fungus Trichoderma sp. Xy24 from a mangrove plant Xylocarpus granatum by using various column chromatography techniques. Their structures were identified as harzianone (1), trichoacorenol (2), and trichodimerol (3) by extensive spectroscopic analysis. Among them, 1 was a harziane diterpene, 2 wasa sesquiterpene alcohol, and 3 was a polyketide with a completely symmetric configuration. Compound 3 exhibited medium inhibitory activity with an IC₅₀ value of 74.6 μMusing a NA (H7N9)/MUNANA model.

Key words: Endophytic fungus, Trichoderma sp. Xy24, Terpenoid, Polyketide, Xylocarpus granatum

CLC Number:

R284

Supporting:

Min Zhang, Ning Li, Ridao Chen, Jianhua Zou, Chunmei Wang, Jungui Dai. Two terpenoids and a polyketide from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(6): 421-424.

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Two terpenoids and a polyketide from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum

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