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Chemical constituents of Pseudolarix kaempferi Gord

Tianzhi Cai, Wen Qi, Lianmei Yang, Guangzhong Tu, Rong Yang, Kehui Xie, Hongzheng Fu*   

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
    2. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
    3. Department of Pharmaceutics, Yangzhou University, Yangzhou 225009, China
    4. Beijing Institute of Microchemistry, Beijing 100091, China
  • Received:2012-05-10 Revised:2012-07-20 Online:2012-09-15 Published:2012-09-15
  • Contact: Hongzheng Fu*

Abstract:

Phytochemical investigations of Pseudolarix kaempferi Gord led to the isolation of 26 known compounds. They were identified as follows: pseudolaric acid D (1), pseudolaric acid A (2), pseudolaric acid B (3), pseudolaric acid C (4), oleana-∆11,13(18)-dien-3β-O-acetyl (5), oleana-∆9(11),12-dien-3β-O-acetyl (6), oleana-∆11,13(18)-dien-3β-hydroxyl (7), oleana-∆9(11),12-dien-3β-hydroxyl (8), celangulatin C (9), celangulatin E (10), 17β-tenacigenin B (11), 11α-O-2-methyl butyryl-12β-O-acetyl tenacigenin B (12), 11α-O-2-methyl butyryl-12β-O-tigloyl tenacigenin B (13), β-sitosterol acetate (14), umbelliferone (15), 5,7-dihydroxyl coumarin (16), xanthotoxin (17), isopimpinellin (18), formononetin (19), calycosin (20), cnidimol B (21), thymine (22), 3-furoic acid (23), 2-furoic acid (24), vanillic acid (25), protocatechuic acid (26). Compounds 524 were isolated from P. kaempferi for the first time. And the 1H and 13C NMR spectra of compound 1 were completely assigned for the first time.

Key words: Pseudolarix kaempferi Gord, Cortex Pseudolaricis, Chemical constituents

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