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Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (1): 21-26.DOI: 10.5246/jcps.2019.01.003

• Original articles • Previous Articles     Next Articles

Study on the anaphylactic shock induced by hemocoagulase for injection based on logistic analysis

Hongjin Gao1, Shaoming Wang1, Yuxing Chen1, Min Chen1*, Shanshan Lu2   

  1. 1. Department of Pharmacy, Fujian Provincial Hospital, Fuzhou 350001, China
    2. Department of Pharmacology, Fujian Medical University, Fuzhou 350108, China
  • Received:2018-09-10 Revised:2018-09-30 Online:2019-01-27 Published:2018-11-05
  • Contact: Tel.: +86-0591-87557768, E-mail: chenmin163com@163.com

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Abstract:

In the present study,we aimed to explore the influencing factors of anaphylactic shock caused by hemocoagulase for injection and to provide a scientific basis for clinical safe medication. The cases reports on the adverse reactions induced by hemocoagulase for injection were collected in Chinese and foreign literatures. The clinical characteristics and influencing factors of anaphylactic shock induced by hemocoagulase for injection were evaluated by logistic regression analysis. In this study, 87 articles including 108 cases (68 cases of anaphylactic shock) were collected. Univariate logistic regression indicated that allergic constitution, daily dose, combined anesthesia, first drug delivery, post-dose time and course of treatment were positively associated with the incidence of anaphylactic shock caused by hemocoagulase for injection (P<0.05). The six above-mentioned factors were included in the multivariate logistic stepwise regression analysis to exclude the effects of confounding factors, and the results suggested that allergic constitution (P = 0.048, OR = 8.242), combined anesthesia (P = 0.024, OR = 22.675) and post-dose time (P = 0.006, OR = 20.255) were associated with the incidence of anaphylactic shock caused by hemocoagulase for injection. The clinicians should pay much more attention to risk factors that may cause anaphylactic shock, such as allergic constitution, combined anesthesia and post-dose time. The clinical pharmacists should strengthen pharmaceutical monitoring and improve the safety of medication. 

Key words: Hemocoagulase for injection, Logistic analysis, Anaphylactic shock

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