Preparation and stability studies of dimethyl curcumin niosomes

doi:10.5246/jcps.2017.04.027

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (4): 265-270.DOI: 10.5246/jcps.2017.04.027

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Preparation and stability studies of dimethyl curcumin niosomes

Rui Li, Defeng Xu, Xingqun Yang, Shouxiu Ma, Xiaoai Ge, Shuwen Zhou^*

School of Pharmaceutical Engineering and Life Science, School of Nursing, Changzhou university, Changzhou 213164, China

Received:2017-02-15 Revised:2017-03-29 Online:2017-04-26 Published:2017-04-02
Contact: Tel.: +86-15189787780, E-mail: zhoushuwen@cczu.edu.cn
Supported by:
The National Natural Science Foundation of China (Grant No. 31271002), Jiangsu Provincial Department of Education Funded Projects (Grant No. 14KJB350001).

Abstract

Abstract:

In the present work, we aimed to optimize the preparation technology of dimethyl curcumin niosomes, improve its solubility and assess its stability. The novel anti-androgen dimethyl curcuminniosomes were prepared by thin-film dispersion-ultrasonic method, and the prescription composition and preparation process were optimized by single-factor investigation method. Certainly, the solubility and quality evaluation of dimethyl curcumin niosomes were also investigated. The average particle size of prepared dimethyl curcumin niosomes was (310.3±0.9) nm. The highest encapsulation rate was 88.1%±1.7%, and the drug-loading amount was 4.03%±1.05%. Moreover, the leakage rate was below 2% within 45 d. Collectively, all these findings indicated that the niosomes, as a vector, could significantly improve the solubility and stability of dimethyl curcumin, offering a theoretical basis for dimethyl curcumin as an anticancer drug in medicine application.

Key words: Niosomes, Dimethyl curcumin, Thin-film dispersion-ultrasonic method, Encapsulation efficiency, Quality evaluation

CLC Number:

R944.9

Supporting:

Rui Li, Defeng Xu, Xingqun Yang, Shouxiu Ma, Xiaoai Ge, Shuwen Zhou. Preparation and stability studies of dimethyl curcumin niosomes[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(4): 265-270.

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Preparation and stability studies of dimethyl curcumin niosomes

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