Comparative study on main compounds in Ginkgo biloba L. base on  mathematical statistics

doi:10.5246/jcps.2019.12.080

Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (12): 843-854.DOI: 10.5246/jcps.2019.12.080

• Original articles • Previous Articles Next Articles

Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics

Yiyi Zhao¹, Ruyi Guo², Haili Yin³, Xintong Fu¹, Yougen Chen¹, Hongzhu Guo^1*

1. Beijing Institute for Drug Control, Beijing Key Laboratory of Analysis and Evaluation on Chinese Medicine, Beijing 102206, China
2. School of Mathematics and Statistics, Beijing Institute of Technology, Beijing 1000081, China
3. College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

Received:2019-09-12 Revised:2019-10-28 Online:2019-12-28 Published:2019-11-03
Contact: Tel.: +86-13911788378, E-mail: guohz@bidc.org.cn
Supported by:
National Administration of Traditional Chinese Medicine Standardization Project (Grant No. ZYBZH-C-HEB-16).

Abstract

Abstract:

In this paper, an HPLC-DAD-ELSD method was developed to determine main 20 components of Ginkgo bilobaL. leaves from different ages and sources, including six flavonol glycosides, five terpene lactones and nine organic acids. Using statistics method and establishing relevant mathematics models, the measured data has proceeded correlation analysis, principal component analysis, and regression statistics and the results showed generality and specific characteristics. We defined p-hydroxybenzoicacid, catechinic, KRcG and ginkgolide A as characteristic indexes representing commonness and speciality of Ginkgo biloba L. leaf. The four characteristic indexes can reflect the quality of Ginkgo biloba L. leaf, and the internal relations between them are significant.The contents of other compounds could define the quantity relation with characteristic markers. It simplified the approach of quality control, and provided a basis for quality control of Ginkgo biloba L.

Key words: Ginkgo biloba L., Statistical analysis, Characteristic markers, Holistic quality evaluation

CLC Number:

R284

Supporting:

Yiyi Zhao, Ruyi Guo, Haili Yin, Xintong Fu, Yougen Chen, Hongzhu Guo. Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(12): 843-854.

References

[1] Ji, S.; He, D.D.; Wang, T.Y.; Han, J.; Li, Z.; Du, Y.; Zou, J.H.; Guo, M.Z.; Tang, D.Q. Separation and characterization of chemical constituents in Ginkgo biloba extract by off-line hydrophilic interaction×reversed-phase two-dimensional liquid chromatography coupled with quadrupole-time of flight mass spectrometry. J. Pharm. Biomed. Anal. 2017, 146, 68-78.

[2] Zhao,Y.Y.; Guo, H.Z.; Chen, Y.G.; Fu, X.T. Simultaneous quantification of flavonol glycosides, terpene lactones, polyphenols and carboxylic acids in Ginkgo biloba leaf extract by UPLC-QTOF-MSE based metabolomic approach. J. Chin. Pharm. Sci. 2017, 26, 789-804.

[3] He, H.H.; Du, X.; Jin, H.H.; Shen, Y.D.; Xu, B.; Wang, R.W.; Yao, J.B. HPLC fingerprint of Ginkgo biloba extracts and the structural identification of common peaks by LC-MS. J. Chin. Pharm. Anal. 2017, 37, 1107-1112.

[4] Xiaoyan, L.; Li, C.; Liu, T.; Ke, H.; Gong, X.C.; Wang, Q.Q.; Zhang, J.B.; Fan, X.H. Chemical analysis, pharmacological activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract. J. Pharm. Biomed. Anal. 2018, 160, 46-54.

[5] Beck, S.; Stengel, J. Mass spectrometric imaging of flavonoid glycosides and biflavonoids in Ginkgo biloba L. Phytochemistry. 2016, 130, 201-206.

[6] Wang, T.Y.; Xiao, J.; Hou, H.P.; Li, P.; Yuan, Z.Y.; Xu, H.R.; Liu, R.; Li, Q.; Bi, K.S. Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2017, 1060, 173-181.

[7] Zhao, Y.Y.; Guo, H.Z.; Chen, Y.G.; Fu, X.T. Holistic quality evaluation of Panax notoginseng extract and injection using an UPLC-QTOF-MSE based metabolomics approach. J. Chin. Pharm. Sci. 2017, 26, 335-345.

[8] Tong, L.K.; Wang, H.; Zhang, X.T.; Guo, N.N.; Han, Y.; Wang, D.D.; Chen, S.Z. Study on chemical constituents of Apocynum venetum L. leaves by LC/MS and determination of the best harvest season. J. Chin. Pharm. Sci. 2018, 27, 251-262.

[9] Yang, Z.M.; Weize, E.; Li, X.X.; Deng, Q.L.; Lei, F.Y.; Li, S.J.; Liu, Y.; Wang, S.J.; Chen, X.F. Comparative study on six alkaloids in Aconiti Lateralis Radix Praeparata and Aconiti Radix in Jiangyou of Sichuan Province based on multivariate statistical analysis. J. Chin. Tradit. Herbal Drugs. 2019, 50, 1461-1471.

[10] Zhou, X.; Zhang, L.; Mao, C.; Kang, X.; Qu, T.; Wang, Y.H.; Yang, R.P. HPLC fingerprints research on decoction pieces of Citri Reticulatae Pericarpium based on chemometrics methods combined with orthogonal partial least square discriminate analysis. J. Chin. Tradit. Herbal Drugs. 2019, 50, 2194-2200.

[11] Dong, L.X.; Ni, J. Research progress of flavonoid biosynthesis, regulation mechanism and influence factors in Ginkgo biloba. J. Chin. Mater. Med. 2017, 42, 3497-3503.

Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 4

Recommended Articles

Metrics

Comments

[1]	Yizheng Sun, Ying Qu, Xiaoyan Liu, Wei Xu, Youbo Zhang. Comparative study on ginsenosides of ginsengs from different regions [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(12): 961-970.
[2]	Yiyi Zhao, Hongzhu Guo, Yougen Chen, Xintong Fu. Holistic quality evaluation of Panax notoginseng extract and injection using an UPLC-QTOF-MSE based metabolomics approach [J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(5): 335-345.
[3]	Yiyi Zhao, Hongzhu Guo, Yougen Chen, Xintong Fu. Simultaneous quantification of flavonol glycosides, terpene lactones, polyphenols and carboxylic acids in Ginkgo biloba leaf extract by UPLC-QTOF-MSE based metabolomic approach [J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(11): 789-804.
[4]	Deqiang Kong, Huiyuan Gao, Xin Li, Jincai Lu, Dan Yuan. Rapid determination of eight aristolochic acid analogues in five Aristolochiaceae plants by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(6): 364-375.