Two glucosylated angucyclines from deep-sea-derived Streptomyces sp. PKU-MA01297

doi:10.5246/jcps.2019.12.079

Abstract

Abstract:

Angucyclines are aromatic polyketides produced by type II polyketide synthase (PKS) exclusively from actinomycetes. These natural products contain hydrolyzable sugar moieties that attach to various positions of the polyketide skeleton and expand the structural diversity. We here report the isolation of two new angucyclines (1 and 2) from the deep-sea-derived Streptomycessp. PKU-MA01297, which was isolated from a sediment sample collected at a depth of 3202 meters from the Indian Ocean. The structures of the two new compounds were elucidated based on comprehensive methods, including NMR, MS and CD analysis. Compounds 1 and 2 featured a 1-O-β-d-glucopyranosyl moiety that has not been reported for angucyclines. Several biological activity assays, including antibacterial, cytotoxicity and anti-inflammatory assays, were carried out, and compounds 1 and 2 showed no activities. These results set the stage for biosynthetic research and more biological activity assays in the future.

Key words: Angucyclines, Deep-sea-derived Streptomyces, Glucopyranosyl moiety

CLC Number:

R284

Supporting:

Xueyang Ma, Guiyang Wang, Zhongyi Zhang, Tongtong Geng, Xiaoxu Sun, Donghui Yang, Xixiang Tang, Ming Ma. Two glucosylated angucyclines from deep-sea-derived Streptomyces sp. PKU-MA01297[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(12): 835-842.

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