Design, synthesis and anti-HIV-1 activity of 4,6-dibenzyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

doi:10.5246/jcps.2011.05.056

Abstract

Abstract:

An effective synthesis method for preparing 4,6-disubstituted pyridinones was reported. Ethyl 3-oxo-4-phenylbutyrate was an important intermediate, by which 6-substituted pyridinones could be prepared. The decarboxylation condition was optimized for compound 4. After protected with a methoxy group, the compound was reacted with BnBr to form the target compound 11. The structures were characterized by ¹H NMR, ¹³C NMR and HRMS, and its enzyme inhibition activity was also determined.

Key words: HIV-1, NNRTIs, Pyridinone analogues, Decarboxylation

CLC Number:

R916

Supporting:

A-Min Li, Xiang-Yi Liu, Xiao-Wei Wang^*, Jun-Yi Liu^*. Design, synthesis and anti-HIV-1 activity of 4,6-dibenzyl-2-oxo-1,2-dihydropyridine-3-carbonitrile [J]. , DOI: 10.5246/jcps.2011.05.056.

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