Pyridin-2(1H)-ones as HIV-1 NNRTIs: a combinatorial optimization strategy

doi:10.5246/jcps.2020.02.006

Abstract

Abstract:

With rapid spread of HIV (human immunodeficiency virus) on a global scale and increasingly severe drug-resistance of it, it is urgently necessary to develop novel effective anti-HIV drugs. Non-nucleoside reverse transcriptase inhibitor (NNRTIs) is one of the most significant antiretroviral drugs for fighting against HIV infection due to their various structures, unique mode of action, good efficacy and low toxicity. Pyridinone derivatives, a type of NNRTIs, have been reported to achieve remarkable development in the past few decades. In this review, we summarized current drug design and medicinal chemistry efforts toward the development of next-generation pyridinones as HIV-1 NNRTIs.

Key words: HIV-1, Reverse transcriptase, Drug-resistance, NNRTIs, Pyridinone derivatives

CLC Number:

R914

Supporting:

Xixi Li, Qian Liu, Tao Sheng, Junyi Liu, Xiaowei Wang. Pyridin-2(1H)-ones as HIV-1 NNRTIs: a combinatorial optimization strategy[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(2): 79-89.

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