Synthesis of telbivudine 3'-O-acetyl-5'-O-phenyl-N-alkylphosphramidates and evaluation of their anti-HBV activities

doi:10.5246/jcps.2011.05.057

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Synthesis of telbivudine 3'-O-acetyl-5'-O-phenyl-N-alkylphosphramidates and evaluation of their anti-HBV activities

Liang-Liang Shi, Hai-Nan Wei, Chang-Mei Cheng^*, Lang-Qiu Chen^*, Yi-Gang Tong

1. College of Chemistry, Key Laboratory of Environmental Friendly Chemistry and Application, the Ministry of Education, Xiangtan University, Xiangtan 411105, China
2. Key Laboratory of Bioorganic Phosphorus and Chemical Biology, the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
3. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China

Received:2011-03-25 Revised:2011-05-30 Online:2011-09-20 Published:2011-09-20
Contact: Chang-Mei Cheng*, Lang-Qiu Chen*

Abstract

CLC Number:

R916.41

Supporting:

Liang-Liang Shi, Hai-Nan Wei, Chang-Mei Cheng^*, Lang-Qiu Chen^*, Yi-Gang Tong . Synthesis of telbivudine 3'-O-acetyl-5'-O-phenyl-N-alkylphosphramidates and evaluation of their anti-HBV activities [J]. , DOI: 10.5246/jcps.2011.05.057.

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Synthesis of telbivudine 3'-O-acetyl-5'-O-phenyl-N-alkylphosphramidates and evaluation of their anti-HBV activities

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