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Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (6): 402-407.DOI: 10.5246/jcps.2019.06.039

• Original articles • Previous Articles     Next Articles

Improved synthesis of key intermediate of grayanotoxin III

Weihao Ma, Zhi Huang, Yanxing Jia*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2019-04-15 Revised:2019-04-30 Online:2019-06-30 Published:2019-05-13
  • Contact: Tel.: +86-010-82805166, E-mail: yxjia@bjmu.edu.cn
  • Supported by:

    Drug Innovation Major Project (Grant No. 2018ZX09711-001-005-005).

Abstract:

A concise improved synthesis of the key intermediate for the synthesis of grayanotoxin III was realized in the present study, featuring a tandem reaction of Michael addition-esterification, Mukaiyama hydration and Mukaiyama dehydrogenaiton.

Key words: Grayanotoxins, Improved synthesis, Tandem reaction, Hydration

CLC Number: 

Supporting: