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Modification of the alkylating agent chlorambucil with spiropiperazinium salts

Gong Li, Qi Sun*, Jing-Rong Cui, Run-Tao Li*   

  1. State Key Laboratory of Natural and Biomimetic drugs; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2010-06-28 Revised:2010-08-12 Online:2010-09-20 Published:2010-09-20
  • Contact: Qi Sun*, Run-Tao Li*

Abstract: In order to improve the antitumor activity and reduce the toxicity of the alkylating agent chlorambucil, a series of spiropiperazinium salts of chlorambucil (8) were designed and synthesized. It was found that compound 8f exhibited potential in vivo activity against H22.

Key words: Chlorambucil, Antitumor activity, Spiropiperazinium, SAR

CLC Number: 

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