A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill.

doi:10.5246/jcps.2016.09.079

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (9): 700-703.DOI: 10.5246/jcps.2016.09.079

• Short communication • Previous Articles Next Articles

A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill.

Xiaoxia Liang*, Lingxi Kong, Min He

Natural Medicine Research Center, College of veterinary medicine, Sichuan Agricultural University, Chengdu 611130, China

Received:2016-04-15 Revised:2016-05-10 Online:2016-09-28 Published:2016-05-26
Contact: Tel.: +86-028-86291470, E-mail: liangxiaoxia@sicau.edu.cn
Supported by:
The Project of Department of Science in Sichuan Province (Grant No. 14ZA0003).

Abstract

Abstract:

A novel homoisoflavone typicalvone A (1), together with two known compounds, n-heneicosane and p-hydroxy benzoic acid, were isolated from Aspidistra typica Baill. The structure of the new compound was elucidated by sepctral techniques, viz. 1D, 2D NMR spectra and HR-ESI-MS. Compared with berberine hydrochloride, typicalvone A showed moderate anti-bacterial activities, especially against the Gram-negative Paeudomonas aeruginosa ATCC-9027 and Escherichia coli ATCC-25922, with MBC values of 1000 and 500 µg/mL, respectively. In addition, it exhibited weak inhibitory activities against the tumour cells.

Key words: Aspidistra typica Baill., Homoisoflavone compound, Antibacterial activity, Antitumor activity

CLC Number:

R284

Supporting:

Xiaoxia Liang, Lingxi Kong, Min He. A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill.[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(9): 700-703.

[1]	Shiqi Xu, Liyan Zhu, Chao Hao, Wenqian Liu, Chenglong Chen, Yongyi Chen, Aiqin Liu. Synthesis of a novel series of amino acid prodrugs based on tegafur and evaluation of their antitumor activity [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(9): 743-753.
[2]	Zipeng Qiao, Qizhi Wang, Jianfu Liu, Mingyuan Wang. Antioxidant and antibacterial activities of the ethyl acetate extracts of endophytic fungi isolated from Ageratum conyzoides L. [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(5): 421-433.
[3]	Beidou Zhou, Zihan Yu, Yugui Tong, Jiali Li, Baocheng Huang, Rongrong Wei, Zhimin Weng, Xin Wang, Zhipeng Ruan, Jian Lin, Caihong Xu, Jianbo Liu. Synthesis of prenylated and geranylated xanthones and their bioactivities [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(8): 564-576.
[4]	Gong Li, Qi Sun, Jing-Rong Cui, Run-Tao Li^. Modification of the alkylating agent chlorambucil with spiropiperazinium salts [J]. , 2010, 19(5): 346-352.
[5]	Wen-Li Mei, Yan-Bo Zeng, Jiao Wu, Hai-Bin Cui, Hao-Fu Dai^*. Chemical composition and anti-MRSA activity of the essential oil from Chinese eaglewood [J]. , 2008, 17(3): 225-229.
[6]	Xing Yan, Yu-Zhuo Ma, Jing-Bo Chen, Ying-Xiang Liu^*. Synthesis and antitumor activities of 2-(E)-(4-cyclopentyloxy-3-methoxylbenzylidene)cyclopentanone derivatives [J]. , 2007, 16(4): 268-271.
[7]	Wen-Jing Hao, Gang-Qiang Li, Miao-Yun Xu, Zhao-Rong Wei, Hai-Min Chen, De-Hu Liu^, Tie-Min Ai^^. Induction and expression of T4 lysozyme gene in Pichia pastoris* [J]. , 2007, 16(1): 33-37.
[8]	LI Rong-po, ZHOU Wei-cheng^*, GUO Yue-fang. Synthesis and Antibacterial Activity of (S)-5-(Heterocycle Methylene) -3-(3-Fluoro-4-morpholin-4-yl-phenyl)-Oxazolidin-2-one Derivatives [J]. , 2006, 15(2): 97-100.
[9]	ZHANG Yong-hong^, WANG Yan-lin, CAI Ai-hua, WANG Qin, CHENG Dong-liang. A Bioactive Diterpene from the Chinese Herb Aster souliei* [J]. , 2004, 13(4): 285-287.
[10]	Xu Zhidong, Liu He, Wang Min, Xiao Sulong, Yang Ming^*, Bu Xianhe . Cobalt (II) Complex of 6,7-Dicycanodipyridoquinoxaline with Antitumor Activities: Synthesis, Crystal Structure and Binding with DNA [J]. , 2002, 11(4): 125-131.
[11]	Song Lin, Xie Yuli, Xie Yuyuan^*. Synthesis and Antitumor Activity of Antineoplaston A10 Analogs [J]. , 2000, 9(2): 77-79.
[12]	Zhou Weicheng, Liu Jinqian, Yu Aizhen, Chen Xiuhua, Zhang Xiuping. Synthesis, Antibacterial and Antitumor Activity of 3-Me thy1-7-oxo-9-fluoro-10-alkyloxy (or Aryloxy)-2,3-dihydro-7H pyrido[1,2,3-de] [1,4]benzoxazine-6-carboxylic Acids and An alogues [J]. , 1999, 8(1): 21-25.
[13]	Kuan-Ke Lu, Fan-Ming Liu, Yao-Zu Chen^*. Synthesis and Antitumor Activity of Podophyllotoxin Analogues [J]. , 1998, 7(4): 182-185.
[14]	Ping Li, Yi-Xian Wang, Guo-jun Xu, Luo-Shan Xu. Antitumor Actinity of Puqietinone, a Novel Alkaloid from the Bulbs of Fritillaria puqiensis [J]. , 1995, 4(4): 217-220.
[15]	Wen-Zheng Liu, Zheng-Hua Li. Synthesis of Sodium 2-[4(S)-4-Amido-3-oxo-2-isoxazolidinyl]-5-oxo-2-tetrahydrofurancarboxylate and Its Antibacterial Activities [J]. , 1993, 2(2): 171-172.

A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill.

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments