Synthesis of RGD-aPEG-Lactoside, A Potential Anti-metastasis Glycoconjugate

Abstract

Abstract: The adhesive interaction between tumor cells and host cells or the extra cellular matrix plays a crucial role in metastasis. Due to the anti-metastasis effects of RGD (Arginyl-Glycyl-Aspartic acid) conjugated with PEG, hybrids of PEG armed RGD and oligosaccharides would have potential regulating effects during the metastasis process. In order to investigate this effect, GD-aPEG-Lactosid, RGD-aPEG-Lactoside glycopeptides armed by PEG were designed and successfully prepared by DCC-HOBt coupling method from aPEG-Lactoside, Boc-Gly-Asp(OBn)-OH.

Key words: RGD, RGD, Oligosaccharides, Oligosaccharides, PEG, PEG, Anti-metastasis, Anti-metastasis, Glycopeptides, Glycopeptides

Supporting:

Niu Limin, Li Qing, Su Bin, Li Hui, Cai Mengshen, Li Zhongjun^*. Synthesis of RGD-aPEG-Lactoside, A Potential Anti-metastasis Glycoconjugate[J]. .

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Synthesis of RGD-aPEG-Lactoside, A Potential Anti-metastasis Glycoconjugate

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