Preparation and characterization of ferromagnetic fluids modified by carboxyl PEG

doi:10.5246/jcps.2012.01.006

Abstract

Abstract:

To prepare and characterize the ferromagnetic fluid of Fe3O4modified by carboxyl PEG (FF/carboxyl PEG) for hyperthermia of tumor, the magnetic nanoparticles (NPs) of Fe3O4were prepared by chemical co-precipitation method, and then modified with carboxyl PEG. The iron content of FFs was determined by spectrophotometric method using o-phenanthroline. The stability of FF/carboxyl PEG was assessed by the sedimentation method. FF/carboxyl PEG was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), infrared spectrometry (IR) and vibrating sample magnetometer (VSM). Heating effect of FF/carboxyl PEG was measured in an alternating magnetic field in vitro. The stability of FF/carboxyl PEG was much better than that of unmodified ferromagnetic fluid. FF/carboxyl PEG was proved to be composed of Fe3O4 by both XRD and IR. TEM showed that the ferromagnetic particles were well-dispersed. The average particle size was calculated as 5 nm by XRD. The saturation magnetization and residual magnetization of FF/carboxyl PEG were 47.01 and 3.41 emu/g, respectively. The coercive force was 6.7 Oe. The specific absorption rate (SAR) of the FF/carboxyl PEG was 63.0 W/g[Fe]. The FF/carboxyl PEG shows the promise for hyperthermia of tumor.

Key words: Ferromagnetic fluid, Fe3O4, Carboxyl PEG, Heating effect, Hyperthermia

CLC Number:

Supporting:

Yan-Fei Zhou, Ling-Ran Du, Chao Zhou, Tian-Yuan Fan^*. Preparation and characterization of ferromagnetic fluids modified by carboxyl PEG[J]. , DOI: 10.5246/jcps.2012.01.006.

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