Abstract: The effects of sodium ferulate(SF), a water-soluble element of Chinese medicine Angelica sinensis diels, on cell-mediated oxidative modification of human low density lipoprotein(LDL) and proliferation of rabbit aortic smooth muscle cells(SMCs) were investigated. Using experimental models of proliferation of cultured rabbit aortic SMCs induced by oxidized LDL(ox-LDL), the extent of oxidation was determined by thiobarbituric acid reactive substances(TBARS) method, MTT colorimetry and ³H-thymidine(³H-TdR) incorporation were used to observe proliferation of SMCs. It showed that SF effectively inhibited cell-mediated oxidation induced by Cu²⁺ in a concentration-dependent manner. At the final concentration of 40, 80, 120 μg·mL^-1, SF could significantly inhibit ³H-TdR incorporation and cell Proliferation in a dose-dependent manner. The results indicated that SF could, in vitro protect LDL against oxidative modification and inhibit the proliferation of SMC, which might be due to its free radical scavenging capacity.

Key words: Sodium ferulate, Sodium ferulate, Oxidation, Oxidation, Antioxidant, Antioxidant, Smooth muscle cells, Smooth muscle cells, Atherosclerosis, Atherosclerosis