Abstract: To access the variance of antibiotic-resistance, we investigated the susceptibility of 30 antimicrobial agents in Campylobacters isolated from 1994 to 1998 using the agar dilution method. All Campylobacter was susceptible to aminoglycoside, imipenem, polymycin B, clarithromycin, josamycin and medemycin. Of the 200 strains of Campylobacters, 3% were resistant to erythromycin; 44.5% to fluoroquinolones. Complete cross-resistance among the fluoroquinolones was observed. The rate of resistance to erythromycin and gentamycin remained relatively lower and stable over the past five years, so these two drugs remain to be the choice for the treatment of Campylobacter infections. The rate of drug resistance to fluoroquinolones of Campylobacters in Beijing area is so high that the application of these drugs should be modulated strictly.

Key words: Campylobacter, Campylobacter, Drug-Resistance, Drug-Resistance