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Pulmonary Delivery of Insulin: Absorption Enhancement of Insulin by Various Absorption Promoters in Rats

Shen Zancong, Cheng Yi, Zhang Qiang*, Wei Shun, Wang Kui   

  1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083
  • Received:1999-03-18 Revised:1999-06-02 Online:2000-03-15 Published:2000-03-15
  • Contact: Zhang Qiang*

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Abstract:

The effects of absorption promoters on the pulmonary absorption of insulin were examined by intratracheal administration of insulin solution in rats. The absorption of insulin from the lung was evaluated by its pharmacological bioavailability (PA%). Results revealed that the coadministration of insulin with 20 mmol·L-1 sodium cholate (PA% = 69.1%), 1% sodium caprilate (PA% = 40.4%), 1% Brij 35 (PA% = 46.6%). 1% Brij 78 (PA% = 53.6%) or GdCl3(PA% = 32.2% at 0.04 mg.kg-1 and 36.3% at 0.2 mg·kg-1) (lanthanide compound) induced a significantly greater decline in blood glucose levels, while coadministration of insulin with adjunvants such as 1% EDIA (PA% = 19.1%), 5% oleic acid (PA% = 20.8%) or LuCl3 (PA% = 25.1%,at 0.2 mg.kg-1) (lanthanide compound) appeared to have no enhancement effect. These observations indicated that the use of proper absorption promoters would be useful for improving the pulmonary absorption of insulin.

Key words: Insulin, Insulin, Intratracheal administration, Intratracheal administration, Hypoglycemic effect, Hypoglycemic effect, Absorption promoters, Absorption promoters, Rat, Rat

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