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Study on the Configuration of Nucleoside Analogues Containing Disaccharide by 1H NMR

Liu Zhongjie, Cui Yuxin*, Liu Xuehui, Min Jimei, Zhang Lihe   

  1. National Research Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083
  • Received:1999-04-08 Revised:1999-08-06 Online:2000-03-15 Published:2000-03-15
  • Contact: Cui Yuxin*

Abstract: A new kind of nucleoside analogues containing disaccharide resulting from Ferrier reaction of glycal was synthesized. Their (a, b, c, d) 1H NMR signals were assigned by GCOSY and GNOESY, the configuration was also determined. The results are in accord with computer-aided molecular simulation.

Key words: Ferrier reaction, Ferrier reaction, Nucleoside analogues, Nucleoside analogues, 1H NMR, 1H NMR

Supporting: