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Gui-Qiu Han, Ping Dai Rong Xue, Byron H.Arison, David C.Lankin, San Bao Hwang
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Abstract: Seven known dibenzocyclooctadiene lignans, tigloylgomisin P(1), angeloylgomisin P(2), gomisin A(3), Schizandrin(4), angeloylgomisin H(5), gomisin B(6) and R(+)-gomisin M1(7) were isolated from Kadsura heteroclita.The conformation of tiglolylgomisin P(1)was established by 2D NMR techniques. Using [3H] platelet activating factor (PAF) binding to human platelet membrane assay, (1), (2) and (7) showed PAF receptor antagonistic activities.
Key words: Kadsura heteroclita, PAF receptor antagonist, Tigloylgomisin P, Angeloylgomisin P, R(+)-gomisin H, Dibenzocyclooctadiene lignans
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Gui-Qiu Han, Ping Dai Rong Xue, Byron H.Arison, David C.Lankin, San Bao Hwang. Dibenzocyclooctadiene Lignans with Platelet-Activating Factor (PAF) Antagonist Activity from Kadsura heteroclita[J]. .
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URL: http://jcps.bjmu.edu.cn/EN/
http://jcps.bjmu.edu.cn/EN/Y1992/V1/I1/20
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