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Dibenzocyclooctadiene Lignans with Platelet-Activating Factor (PAF) Antagonist Activity from Kadsura heteroclita

Gui-Qiu Han, Ping Dai Rong Xue, Byron H.Arison, David C.Lankin, San Bao Hwang   

  1. 1. School of Pharmaceutical Sciences; Beijing Medical University; Beijing 100083;
    2. Dept.of Chemistry; Lanzhou Military Medical School; Lanzhou 730020;
    3. Merck Sharp & Dohme Res.Lab; Rahway; NJ 07065; USA;
    4. G.D.Searle & Co; Skokie; IL 60077; USA;
    5.Cytomed Inc.; Cambridge; MA 01701; USA.
  • Received:1992-01-03 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

Abstract: Seven known dibenzocyclooctadiene lignans, tigloylgomisin P(1), angeloylgomisin P(2), gomisin A(3), Schizandrin(4), angeloylgomisin H(5), gomisin B(6) and R(+)-gomisin M1(7) were isolated from Kadsura heteroclita.The conformation of tiglolylgomisin P(1)was established by 2D NMR techniques. Using [3H] platelet activating factor (PAF) binding to human platelet membrane assay, (1), (2) and (7) showed PAF receptor antagonistic activities.

Key words: Kadsura heteroclita, PAF receptor antagonist, Tigloylgomisin P, Angeloylgomisin P, R(+)-gomisin H, Dibenzocyclooctadiene lignans

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