Exploration for a Natural Selenium Supplement-Characterization and Bioactivities of Se-containing Polysaccharide from Garlic

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Exploration for a Natural Selenium Supplement-Characterization and Bioactivities of Se-containing Polysaccharide from Garlic

Ming Yang, Kui Wang, Lin Gao, Yu-Ting Han, Jing-Fen Lu, Tong-Tong Zou

1. National Laboratories of Natural and Biomimetic Drugs; Beijing Medical University, Beijing, 100083;
2. School of Public Health, Beijing Medical University, Beijing 100083

Received:1991-10-11 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

Abstract

Abstract: A Se-containing polysaccharide (Se-GPS), with average molecular weight of 1.5×10⁴ was isolated from Hubei Enshi garlic (Allium sativum L.) and purified by means of Sephadex G25 to G200 chromatographies. Its chemical homogeneity and composition were studied by optical rotation, HPLC and paper chromatographical methods. The abilities of scavenging active oxygen free radicals and inhibiting the damage of erythrocyte membrane by SiO2 were established by spin trapping ESR studies. Se-GPS was shown to inhibit human cytomegalovirus by plague reduction assays and cytopathogenic effect tests.

Key words: Selenium, Polysaccharide, Garlic, Allium sativum

Supporting:

Ming Yang, Kui Wang, Lin Gao, Yu-Ting Han, Jing-Fen Lu, Tong-Tong Zou. Exploration for a Natural Selenium Supplement-Characterization and Bioactivities of Se-containing Polysaccharide from Garlic[J]. .

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Exploration for a Natural Selenium Supplement-Characterization and Bioactivities of Se-containing Polysaccharide from Garlic

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