Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state

doi:10.5246/jcps.2019.09.063

Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (9): 665-672.DOI: 10.5246/jcps.2019.09.063

• Original articles • Previous Articles

Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state

Chunxia Tan^1*, Yali Wang²

1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Key Laboratory of Traditional Chinese Medicine Quality and Standard, Gansu University of Chinese Medicine, Lanzhou 730000, China

Received:2019-05-27 Revised:2019-06-13 Online:2019-09-30 Published:2019-08-15
Contact: Tel.: +86-13519641096, E-mail: tancx@sina.com
Supported by:
Key Laboratory of Traditional Chinese Medicine Quality and Standard, Gansu University of Chinese Medicine, Lanzhou, China (Grant No. ZYZL18-006).

Abstract

Abstract:

Ophiopogonis polysaccharide-iron (III) (OPI) was prepared and characterized in the present study. The optimum condition for preparing OPI was as follows: OP and trisodium citrate were mixed at a weight ratio of 4:1 and reacted in a water bath at 70 °C for 3 h within the pH range of 8.0–8.5. Aggregation morphology or structure of OPI in aqueous solution and solid state was studied by scanning electron microscopy, transmission electron microscopy and small-angle X-ray diffraction. In aqueous solution, OPI could self-assemble into micron vesicles with flower-shaped morphology. Results of X-ray diffraction showed OPI with layered structure. A core-shell model was proposed for OPI.

Key words: Supramolecular complexes, Ophiopogonis polysaccharide-iron (III), Self-assembly, Flower-shaped morphology, Layered structure

CLC Number:

Supporting:

Chunxia Tan, Yali Wang. Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(9): 665-672.

References

[1] Neary, E.R. The use of molybdenized ferrous sulfate in the treatment of true iron deficiency anemia of pregnancy. Am. J. Med. Sci. 1946, 1, 7682.

[2] Predoi D. A study on iron oxide nanoparticles coated with dextrinobtained by coprecipitation. Digest J. Nanomaterials Biostructures. 2007, 2, 169-173.

[3] Berry, C.C.; Wells, S.; Charles, S.; Curtis, A.S. Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. Biomaterials. 2003, 24, 4551-4557.

[4] Locatelli, F.; Pisoni, R.L.; Combe, C.; Bommer, J.; Andreucci, V.E.; Piera, L.; Greenwood, R.; Feldman, H.I.; Port, F.K.; Held, P.J. Anaemia in haemodialysis patients of five European countries: association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol. Dial. Transplant. 2004, 19, 121-132.

[5] Geisser, P. Safety and efficacy of iron (III)-hydroxide polymaltose complex. Arzneimittelforschung. 2007, 57, 439-452.

[6] Liu, T.C.; Lin, S.F.; Chang, C.S.; Yang, W.C.; Chen, T.P. Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia: a taiwanese study. Int. J. Hematol. 2004, 80, 416-420.

[7] Shi, J.M.; Cheng, C.L.; Zhao, H.T.; Jing, J.; Gong, N.; Lu, W.H. In vivo anti-radiation activities of the Ulva pertusa polysaccharides and polysaccharide-iron (III) complex. Int. J. Biol. Macromol. 2013, 60, 341-346.

[8] Zhang, Z.S.; Wang, X.M.; Han, Z.P.; Yin, L.; Zhao, M.X.; Yu, S.C. Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC). Bioorg. Med. Chem. Lett. 2012, 22, 489-492.

[9] Coe, E.M.; Bowen, L.H.; Speer, J.A.; Bereman, R.D. Comparison of polysaccharide iron complexes used as iron supplements. J. Inorg. Biochem. 1995, 57, 287-292.

[10] Wang, P.P.; Zhang Y.; Wang K.P.; Li, K. Effects of angelica sinensis polysaccharide-iron complex on hemolytic anemia and bone marrow injury in mice. J. Chin. Pharm. Sci. 2008, 17, 197-202

[11] Tang, D.L.; Sun, W.Q.; Zeng, H.T.; Lu, Y.; Mei, E.D.; Liu, L.P. Studies on the preparation, properties of alginate-iron (III) complex. Chin. Pharm. J. 2016, 51, 1513-1518.

[12] Xu, L.L.; Zhan, X.B.; Zeng, Z.W.; Li, X.; Wang, S.L.; Xie, T. Study on preparation and chemical characterization of iron (III)-polygonatum odoratum polysaccharides Complex. Chin. Pharm. J. 2012, 47, 331-334.

[13] Xiong, S.L.; Li, A.L.; Huang, N.; Lu, F.; Hou, D.B. Antioxidant and immunoregulatory activity of different polysaccharide fractions from tuber of Ophiopogon japonicus. Carbohydr. Polym. 2011, 86, 1273-1280.

[14] Jin, M.L.; Zhao, K.; Huang, Q.S.; Xu, C.L.; Shang, P. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: a review. Carbohydr. Polym. 2012, 89, 713-722.

[15] Zhou, P.; Xie, M.Y.; Nie, S.P.; Wang, X.R. Primary structure and configuration of tea polysaccharide. Sci. China C Life Sci. 2004, 47, 416-424.

[16] Suresh, G.; Manjunath, K.; Venkateswarlu, V.; Satyanarayana, V. Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles. AAPS Pharm. Sci. Tech. 2007, 8, E162-E170.

[17] Chen, X.M.; Jin, J.; Tang, J.; Wang, Z.F.; Wang, J.J.; Jin, L.Q.; Lu, J.X. Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus. Carbohydr. Polym. 2011, 83, 749-754.

[18] Xu, D.S.; Feng, Y.; Lin, X.; Deng, H.L.; Fang, J.N.; Dong, Q. Isolation, purification and structural analysis of a polysaccharide MDG-1 from Ophiopogon japonicus. Acta Pharm. Sin. 2005, 40, 636-639.

[19] Coe, E.M.; Bowen, L.H.; Speer, J.A.; Wang, Z.H.; Sayers, D.E.; Bereman, R.D. The recharacterization of a polysaccharide iron complex (Niferex). J. Inorg. Biochem. 1995, 58, 269-278.

[20] Kudasheva, D.S.; Lai, J.; Ulman, A.; Cowman, M.K. Structure of carbohydrate-bound polynuclear iron oxyhydroxide nanoparticles in parenteral formulations. J. Inorg. Biochem. 2004, 98, 1757-1769.

[21] Yu, X.; Yang, H.S. Pyrethroid residue determination in organic and conventional vegetables using liquid-solid extraction coupled with magnetic solid phase extraction based on polystyrene-coated magnetic nanoparticles. Food Chem. 2017, 217, 303-310.

[22] Liu, Q.; Wu, J.E.; Lim, Z.Y.; Aggarwal, A.; Yang, H.S.; Wang, S.F. Evaluation of the metabolic response of Escherichia coli to electrolysed water by 1H NMR spectroscopy. LWT - Food Sci. Technol. 2017, 79, 428-436.

[23] Chen, L.; Wu, J.E.; Li, Z.M.; Liu, Q.; Zhao, X.; Yang, H.S. Metabolomic analysis of energy regulated germination and sprouting of organic mung bean (Vigna radiata) using NMR spectroscopy. Food Chem. 2019, 286, 87-97.

[24] Katagiri, K.; Ohta, K.; Koumoto, K.; Kurosu, K.; Sasaki, Y.; Akiyoshi, K. Templated nucleation of hybrid iron oxide nanoparticles on polysaccharide nanogels. Colloid Polym. Sci. 2013, 291, 1375-1380

[25] Berg, K.A.; Bowen, L.H.; Hedges, S.W.; Bereman, R.D.; Vance, C.T. Identification of ferrihydrite in polysaccharide iron complex by Mossbauer spectroscopy and X-ray diffraction. J. Inorg. Biochem. 1984, 22, 125-135.

Self-assembly of Ophiopogonis polysaccharide-iron (III) complex in aqueous solution and solid state

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