A novel preparation of Panax japonicas with high bioequivalence of ginsenoside Rg3

doi:10.5246/jcps.2019.09.062

Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (9): 650-664.DOI: 10.5246/jcps.2019.09.062

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A novel preparation of Panax japonicas with high bioequivalence of ginsenoside Rg3

Xinyu Shen^1,2, Xingchen Wang³, Caihong Gu⁴, Feng Yan⁵, Bo Pan^1,2, Lizeng Gao^1,2, Bingchun Yan^1,2*, Qi Liu^1,2*, Rong Hu^1,2*

1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China
3. The People’s Hospital of Rugao, Rugao 226500, China
4. Jiangsu Lianhuan Pharmaceutical Group Co., Ltd., Yangzhou 225009, China
5. Jiangsu Yangnong Chemical Group Co., Ltd., Yangzhou 225009, China

Received:2019-06-28 Revised:2019-07-19 Online:2019-09-30 Published:2019-08-15
Contact: Tel.: +86-13901457381; +86-13665200137; +86-18166822359, E-mail: bcyan@yzu.edu.cn; liuqi@yzu.edu.cn; ronghu@yzu.edu.cn
Supported by:
Postgraduate Research ?Innovation Program of Yangzhou University (Grant No. XKYCX18_128).

Abstract

Abstract:

In the present study, we aimed to prepare Panax japonicus tablets and carry out quality inspection. Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation, and quality inspection was carried out according to Pharmacopoeia regulations. The plasma concentration of animals with self-made Panax japonicus tablets or ginsenoside Rg3 in single-doseintragastric administration was determined by high-performance liquid chromatography (HPLC). The pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.0 software.The quality inspection of self-made Panax japonicus tablets met the requirements of Chinese Pharmacopoeia (2015 edition), and this preparation had high bioequivalence of ginsenoside Rg3. The preparation of Panax japonicus tablets was reasonable and highly qualified. Moreover, this new Panax japonicus preparation showed better profiles in oral absorption and utilization. This study provided evidence for the industrial production and clinical application of Panax japonicus tablets.

Key words: Panax japonicas tablets, Tablet quality, Ginsenoside Rg3, Bioequivalence

CLC Number:

R943

Supporting:

Xinyu Shen, Xingchen Wang, Caihong Gu, Feng Yan, Bo Pan, Lizeng Gao, Bingchun Yan, Qi Liu, Rong Hu. A novel preparation of Panax japonicas with high bioequivalence of ginsenoside Rg3[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(9): 650-664.

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A novel preparation of Panax japonicas with high bioequivalence of ginsenoside Rg3

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