http://jcps.bjmu.edu.cn

• Full Papers • Previous Articles     Next Articles

Isolation and Characterization of Platelet-Activating Factor (PAF) Inhibitors from Zanthoxylum schinifolium

Mei-Fang Hong, Jing-Xian Pan, Tian-Yi Jiang, Chang-Ling Li, Gui-Qiu Han   

  1. 1. National Laboratory of Natural and Biomimetic Drugs; Beijing Medical University; Beijing 100083;
    2. Nanjing College of Traditional Chinese Medicine; Nanjing 210029
  • Received:1991-10-15 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

Abstract: Two new compounds, schinifolin I and acetoxyschinifolin II, along with five known compounds (auraptenIII, dictamnine IV, scoparone V, skimmianine VI, and β-sitosterol VII) were isolated from the roots of Zanthoxylum schinifolium Sieb.et Zucc.col- lected in Yixing County, Jiangsu Province. The structure determination was based upon spectroscopic analysis(UV, IR, MS, PMR, CMR, 2D NMR).The structures of schinifolin I and acetoxyschinifolin II were elucidated as 7[(3',7'-dimethyl-2',6'-octadienyl)] oxy-8-methoxy-2H-1-benzopyran-2-one, and 7[(3',7'-dimethyl-5'-acetoxy-2',6'-octadienyl)]oxy-8-methoxy-2H-1-benzopyran-2-one, respectively. In the test of platelet aggregation caused by PAF, compounds I, II, III and V showed inhibitory activity.

Key words: Zanthoxylum schinifolium, Schinifolin, Acetoxyschinifolin, Platelet-activating factor(PAF)

Supporting: