Abstract: Two new compounds, schinifolin I and acetoxyschinifolin II, along with five known compounds (auraptenIII, dictamnine IV, scoparone V, skimmianine VI, and β-sitosterol VII) were isolated from the roots of Zanthoxylum schinifolium Sieb.et Zucc.col- lected in Yixing County, Jiangsu Province. The structure determination was based upon spectroscopic analysis(UV, IR, MS, PMR, CMR, ²D NMR).The structures of schinifolin I and acetoxyschinifolin II were elucidated as 7[(3',7'-dimethyl-2',6'-octadienyl)] oxy-8-methoxy-2H-1-benzopyran-2-one, and 7[(3',7'-dimethyl-5'-acetoxy-2',6'-octadienyl)]oxy-8-methoxy-2H-1-benzopyran-2-one, respectively. In the test of platelet aggregation caused by PAF, compounds I, II, III and V showed inhibitory activity.

Key words: Zanthoxylum schinifolium, Schinifolin, Acetoxyschinifolin, Platelet-activating factor(PAF)