Efficacy and safety of ACEI plus tanshinone for acute exacerbation of pulmonary heart disease: a meta-analysis

doi:10.5246/jcps.2022.11.072

Abstract

Abstract:

Acute exacerbation of pulmonary heart disease (AECPHD) is life-threatening. Conventional therapy plus angiotensin-converting enzyme inhibitors (ACEI) is not always practical. Recent trials have suggested the beneficial effects of the combination of ACEI and tanshinone on AECPHD. In the present study, we aimed to evaluate its efficacy and safety by meta-analysis systematically. The result indicated that combination of ACEI and tanshinone was more effective than ACEI monotherapy in AECPHD, as represented by treatment efficiency and mean pulmonary arterial pressure, PaCO2, and PaO2. However, the incidence of adverse events of combined therapy was higher than the control group, while the result of the analysis for adverse events was unstable. Further large-scale, multicenter, and rigorously designed randomized controlled trials (RCT) are needed to evaluate the efficacy and safety of combined therapy.

Key words: Enalapril, Captopril, Tanshinone, Meta-analysis, AECPHD

Supporting:

Supplementary Figure 1. Funnel plot of treatment efficiency.

Supplementary Figure 2. Egger’s test of treatment efficiency.

Supplementary Figure 3. Forrest plot of treatment efficiency after trimming and filling.

Supplementary Figure 4. Funnel plot of treatment efficiency after trimming and filling.

Supplementary Figure 5. Sensitivity analysis of of treatment efficiency.

Supplementary Figure 6. Funnel plot of mPVP.

Supplementary Figure 7. Egger’s test of mPVP.

Supplementary Figure 8. Forrest plot of mPVP after trimming and filling.

Supplementary Figure 9. Funnel plot of mPVP after trimming and filling.

Supplementary Figure 10. Sensitivity analysis of of mPVP.

Supplementary Figure 11. Funnel plot of PaCO_2.

Supplementary Figure 12. Forrest plot of PaCO₂ after trimming and filling.

Supplementary Figure 13. Funnel plot of PaCO₂ after trimming and filling.

Supplementary Figure 14. Sensitivity analysis of of PaCO_2.

Supplementary Figure 15. Funnel plot of PaO₂.

Supplementary Figure 16. Forrest plot of PaO₂ after trimming and filling.

Supplementary Figure 17. Funnel plot of PaO₂ after trimming and filling.

Supplementary Figure 18. Sensitivity analysis of of PaO_2.

Supplementary Figure 19. Funnel plot of Adverse events .

Supplementary Figure 20. Forrest plot of adverse events after trimming and filling.

Supplementary Figure 21. Funnel plot of adverse events after trimming and filling.

Supplementary Figure 22. Sensitivity analysis of of adverse events.

Min Li, Lulu Chang, Xiangfeng Yue, Shuzhang Du. Efficacy and safety of ACEI plus tanshinone for acute exacerbation of pulmonary heart disease: a meta-analysis[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(11): 853-865.

Figures/Tables 10

Table 1. Characteristics of the included studies.

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