Determination the content of gypsum fibrosum in Xiaokening tablets by powder X ray diffraction method

doi:10.5246/jcps.2019.03.018

Abstract

Abstract:

The research on the application of X-ray diffraction in the quantitative analysis of Chinese medicines is rare. The main reason is that the technical problems related to the internal standard and the selection of quantitative peaks are not well solved, and the accuracy and precision of the results are not satisfactory. This study employed the concept of mass absorption coefficient based on the internal standard method, and the full spectrum fitting and quantitative methods were used to solve the above technical problems. The sample was blended, the internal standard substance of zinc oxide was fully ground, and tablets were prepared by positive pressure method. Under certain instrumental conditions, the PXRD pattern was obtained by scanning. The percentage of gypsum fibrosum in Xiaokening tablet was obtained by quantitative analysis of full spectrum fitting internal standard by TOPAS software. The method was investigated by methodology. At the same time, the method was compared by ion chromatography, and SPSS software was used to make a significant t test on the results of the two methods. After the investigation, the average standard recovery rate of CaSO₄·2H₂O was 99.06% (RSD=3.02%); and the recovery rate for simulated samples was 96.7%. The method had good specificity. After statistical analysis, there was no significant difference between the new PXRD method and the traditional method of ion chromatography.

Key words: Powder X ray diffraction, Full spectrum fitting internal standard quantitative method, Xiaokening tablet, Gypsum fibrosum

CLC Number:

R917

Supporting:

Jianping Zhang, Xinxin Feng, Dong Wang. Determination the content of gypsum fibrosum in Xiaokening tablets by powder X ray diffraction method[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(3): 186-194.

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