Sesquiterpenes from Artemisia giraldii var. longipedunculata

doi:10.5246/jcps.2018.08.058

Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (8): 576-581.DOI: 10.5246/jcps.2018.08.058

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Sesquiterpenes from Artemisia giraldii var. longipedunculata

Yang Xue¹, Chen Zhang¹, Zhibo Wu², Puming Zhang¹, Mingbo Zhao¹, Yong Jiang^1*, Pengfei Tu^1*

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Alashan League Institute of Forestry Sand Control, Alashan 750306, China

Received:2018-05-22 Revised:2018-07-08 Online:2018-09-04 Published:2018-07-15
Contact: Tel.: +86-010-82802719; +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
Supported by:
National Natural Science Foundation of China (NSFC, Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

Abstract

Abstract:

A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including12-hydroxy-α-cyperone (1), 1β,6α-dihydroxyeudesma-4(15)-ene (2), carainterol A (3), oplodiol (4),douglanin (5), 1α-hydroxyisodauc-4-en-15-al (6), 3α,6α-dihydroxybisabola-4,10-diene (7), 4α,5β-dihydroxybisabola-2,10-diene(8), opposit-4(15)-ene-1β,7-diol (9), and saniculamoid D (10), respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the ¹³C NMR data of 1 were fully assigned based on the 2D NMR data for the first time.

Key words: Artemisia giraldii var. longipedunculata, Sesquiterpene, Eudesmane

CLC Number:

R284

Supporting:

Yang Xue, Chen Zhang, Zhibo Wu, Puming Zhang, Mingbo Zhao, Yong Jiang, Pengfei Tu. Sesquiterpenes from Artemisia giraldii var. longipedunculata[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(8): 576-581.

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Sesquiterpenes from Artemisia giraldii var. longipedunculata

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