Sesquiterpenes from Alisma plantago-aquatica

doi:10.5246/jcps.2016.08.069

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (8): 614-620.DOI: 10.5246/jcps.2016.08.069

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Sesquiterpenes from Alisma plantago-aquatica

Jingyi Yu, Jun Wang, Hong Liang, Qingying Zhang^*, Shizhong Chen, Pengfei Tu

State Key Laboratory of Natural and Biomimetic Drugs; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2016-05-24 Revised:2016-06-15 Online:2016-09-01 Published:2016-06-20
Contact: Tel.: +86-010-82801725, E-mail: qyzhang@bjmu.edu.cn
Supported by:
The National Science and Technology Major Project of “Technological study on the safety and standards of Chinese materia medica” (Grant No. 2014ZX09304307-001-011) and Chinese materia medica supporting program of “Quality control base construction of Chinese material medica including Isatidis Radix, Carthami Flos, etc” by Ministry of Industry and Information Technology of Peoples Republic of China.

Abstract

Abstract:

Six sesquiterpenes, including three guaiane type sesquiterpenes (1–3), one oplopanone type sesquiterpene (4), one xanthane type sesquiterpene (5) and one salvialane type sesquiterpene (6), were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide (1), alismol (2), orientalol B (3), oplopanone (4), gibberodione (5), and 7α,10α-epoxy-salvialan-10β-ol (6), respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.

Key words: Alisma plantago-aquatica, Sesquiterpenes, Biogenetic pathway

CLC Number:

R284

Supporting:

Jingyi Yu, Jun Wang, Hong Liang, Qingying Zhang, Shizhong Chen, Pengfei Tu. Sesquiterpenes from Alisma plantago-aquatica[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 614-620.

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Sesquiterpenes from Alisma plantago-aquatica

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