Synthesis and anticancer activity study of curcumin-related compounds containing benzyl piperidone

doi:10.5246/jcps.2015.08.066

Abstract

Abstract:

Sixteen curcumin-related compounds containing benzyl piperidonewere synthesized and evaluated for their anticancer activity by the MTT assay towards cultured prostate cancer (PC-3), pancreatic cancer (BxPC-3), colon cancer (HT-29), and lung cancer (H1299) cells. Compounds A1 and B3 exhibited potent growth inhibitory effects againstthese cells in culture. The IC₅₀ values of these compounds were lower than 1 µM in all four cell lines.

Key words: Curcumin-related compounds, Synthesis, Anticancer activity

CLC Number:

R916

Supporting:

Daiying Zhou, Suqing Zhao, Xi Zheng, Zhiyun Du, Kun Zhang. Synthesis and anticancer activity study of curcumin-related compounds containing benzyl piperidone[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(8): 524-529.

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