Methoxyl methyl ether isoamylene quercetin, a quercetin derivative, protects rat aorta endothelial cells against oxidation and apoptosis

doi:10.5246/jcps.2013.04.051

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Methoxyl methyl ether isoamylene quercetin, a quercetin derivative, protects rat aorta endothelial cells against oxidation and apoptosis

Xiumei Liu, Xiaoyan Liu, Yinye Wang^*

1. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. People's Hospital of Zhengzhou, Zhengzhou, Henan 450003, China

Received:2012-09-10 Revised:2012-11-05 Online:2013-07-10 Published:2013-07-10
Contact: Yinye Wang*

Abstract

Abstract:

Methoxyl methyl ether isoamylene quercetin (MIAQ) is one of the newly synthesized quercetin derivatives. The present study investigated the effect of MIAQ on rat aorta endothelial cells (RAECs) injured by hydrogen peroxide (H2O2), as well as the potential mechanisms. We observed that MIAQ at 2.5-10 μmol/L significantly enhanced the viability of injured RAECs, and the effect was more potent than quercetin and α-tocopherol. However, MIAQ at the same concentration failed to show anti-oxidant activity in a cell-free system. In H2O2-injured endothelial cells treated with MIAQ (5-10 μmol/L), the level of nitric oxide (NO) and malondialdehyde was decreased, and the activities of superoxide dismutase and glutathione peroxidase was enhanced. In addition, RAECs treated with MIAQ (2.5-10 μmol/L) exhibited significant inhibiting apoptosis. In conclusion, MIAQ had protective effect on RAECs, possibly through increasing NO production and antioxidases activities, as well as inhibiting apoptosis. These findings suggest that MIAQ is possibly beneficial in the prevention of atherosclerosis and other diseases related to endothelial injury.

Key words: Methoxyl methyl ether isoamylene quercetin, Rat aorta endothelial cells, Nitric oxide, Anti-oxidation, Anti-apoptosis

CLC Number:

R965

Supporting:

Xiumei Liu, Xiaoyan Liu, Yinye Wang^*. Methoxyl methyl ether isoamylene quercetin, a quercetin derivative, protects rat aorta endothelial cells against oxidation and apoptosis [J]. , DOI: 10.5246/jcps.2013.04.051.

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Methoxyl methyl ether isoamylene quercetin, a quercetin derivative, protects rat aorta endothelial cells against oxidation and apoptosis

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