Identification of the metabolites of baicalein in rat serum

doi:10.5246/jcps.2011.03.034

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Identification of the metabolites of baicalein in rat serum

Lin Yang, Xiao-Yu Guo^*, Qi-Fang Wang, Ying Chen, Yi-Xin Che, Qing-Ming Che^*

1. Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2011-03-01 Revised:2011-04-22 Online:2011-05-06 Published:2011-05-06
Contact: Xiao-Yu Guo*, Qing-Ming Che*

Abstract

Abstract:

Baicalein, the aglycon of baicalin, is one of the main bioactive flavones in Scutellaria baicalensis Georsi. Five metabolites (M1-M5) and the parent drug (M0) were identified in rat serum after oral administration of baicalein at a dose of 200 mg/kg using the HPLC-DAD and LC-MS/MS methods. Based on the results, the possible metabolic pathway of baicalein in rat serum was proposed.

Key words: Baicalein, Flavones, Metabolite, LC-MS/MS, HPLC-DAD

CLC Number:

R969.1

Supporting:

Lin Yang, Xiao-Yu Guo^*, Qi-Fang Wang, Ying Chen, Yi-Xin Che, Qing-Ming Che^* . Identification of the metabolites of baicalein in rat serum[J]. , DOI: 10.5246/jcps.2011.03.034.

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Identification of the metabolites of baicalein in rat serum

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