HH-A, one of the honokiol derivatives, exhibits a function that improves the oxygen-carrying capacity of blood in rats under hypoxia. Additionally, in a brain ischemic injury animal model, HH-A significantly reduced the degree of hypoxia in brain tissue. The oxygen-carrying capacity of hemoglobin (Hb) in red blood cells is crucial to tissue oxygen demand. Biomolecular interaction analysis with surface plasmon resonance technology and the molecular docking analysis was used to explore the potential interaction between HH-A and Hemoglobin subunit beta, indicating the potential effect of HH-A on the affinity of Hb-O2 by binding to Hb. These findings suggested that HH-A interacts with Hb to enhance hypoxia tolerance and alleviate brain injury caused by ischemia.
Zhang, Y.Y. et al. / J. Chin. Pharm. Sci. 2024, 33 (2), 98–109.
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