青椒根抑制血小板活化因子(PAF)活性成分的分离鉴定

青椒根抑制血小板活化因子(PAF)活性成分的分离鉴定

洪美芳, 潘竞先, 蒋天羲, 李长龄, 韩桂秋

1. 天然药物及仿生药物国家重点实验室, 北京医科大学, 北京 100083
2. 南京中医学院, 南京 210029

收稿日期:1991-10-15 修回日期:1992-03-10 出版日期:1992-06-15 发布日期:1992-06-15

Isolation and Characterization of Platelet-Activating Factor (PAF) Inhibitors from Zanthoxylum schinifolium

Mei-Fang Hong, Jing-Xian Pan, Tian-Yi Jiang, Chang-Ling Li, Gui-Qiu Han

1. National Laboratory of Natural and Biomimetic Drugs; Beijing Medical University; Beijing 100083;
2. Nanjing College of Traditional Chinese Medicine; Nanjing 210029

Received:1991-10-15 Revised:1992-03-10 Online:1992-06-15 Published:1992-06-15

摘要/Abstract

摘要： 自青椒(Zanthoxylum schinifolium Sieb.et Zucc.) 根分离得到7个化合物, 其中2个为新结构定名为青椒内酯(schinifolin I), 乙酰氧青椒内酯(acetoxyschinifolin II), 其他5个为已知化合物, 葡萄内酯(aurapten III), 白鲜碱(dictamnine IV), 滨嵩内酯(scoparone V), 茵芋碱(skimmianine VI), β-谷甾醇(β-sitosterol VII)。根据理化性质及光谱数据, I, II化合物鉴定为7氧代(3',7'-二甲基-2',6'-辛二烯)-8-甲氧基香豆素及7氧代(3',7'-二甲基-5'-乙酰氧基-2',6'-辛二烯基)8-甲氧基香豆素, 化合物I、II、III, V在由血小板活化因子(PAF)引起的血小板聚集实验中, 具有拮抗血小板聚集的活性。

关键词: 青椒, 青椒内脂, 乙酰氧青椒内酯, 血小板活化因子(PAF)

Abstract: Two new compounds, schinifolin I and acetoxyschinifolin II, along with five known compounds (auraptenIII, dictamnine IV, scoparone V, skimmianine VI, and β-sitosterol VII) were isolated from the roots of Zanthoxylum schinifolium Sieb.et Zucc.col- lected in Yixing County, Jiangsu Province. The structure determination was based upon spectroscopic analysis(UV, IR, MS, PMR, CMR, ²D NMR).The structures of schinifolin I and acetoxyschinifolin II were elucidated as 7[(3',7'-dimethyl-2',6'-octadienyl)] oxy-8-methoxy-2H-1-benzopyran-2-one, and 7[(3',7'-dimethyl-5'-acetoxy-2',6'-octadienyl)]oxy-8-methoxy-2H-1-benzopyran-2-one, respectively. In the test of platelet aggregation caused by PAF, compounds I, II, III and V showed inhibitory activity.

Key words: Zanthoxylum schinifolium, Schinifolin, Acetoxyschinifolin, Platelet-activating factor(PAF)

Supporting:

洪美芳, 潘竞先, 蒋天羲, 李长龄, 韩桂秋. 青椒根抑制血小板活化因子(PAF)活性成分的分离鉴定[J]. .

Mei-Fang Hong, Jing-Xian Pan, Tian-Yi Jiang, Chang-Ling Li, Gui-Qiu Han. Isolation and Characterization of Platelet-Activating Factor (PAF) Inhibitors from Zanthoxylum schinifolium[J]. .