丹参酚酸类对羟自由基的捕捉作用

丹参酚酸类对羟自由基的捕捉作用

刘雨, 张均田

中国医学科学院药物研究所, 北京100050

收稿日期:1992-12-01 修回日期:1993-05-29 出版日期:1994-06-15 发布日期:1994-06-15

Hyroxyl Radical Scavenging Effect of Salvianolic Acids

Yu Liu, Jun-Tian Zhang

Institute of Materia Medica, Chinese Academy of Medical Sciences, BeiJing 100050

Received:1992-12-01 Revised:1993-05-29 Online:1994-06-15 Published:1994-06-15

摘要/Abstract

摘要： 研究了丹参酚酸类对EDTA-H2O2-Fe²⁺和VitC-H2O2-Fe²⁺系统中水杨酸的羟基化作用。在后一体系中, 这类化合物剂量依赖性地抑制羟化作用, 其作用强度和抗脂质过氧化基本一致。而在前一体系中, 作用较复杂。大多数丹参酚酸类剂量依赖性地抑制水杨酸羟化作用, 但丹参酚酸A作用例外-和VitC作用相似, 丹参酚酸A在低剂量时促进水杨酸羟基化作用, 而在高剂量时则抑制。这类化合物能与铁离子结合或络合, 但其络合常数较EDTA-铁络合常数低二个数量级以上, 因而认为丹参酚酸类化合物可能具有羟自由基捕捉作用。

关键词: 丹参酚酸类, 羟自由基, 水杨酸羟化作用, 表现络合常数, 铁离子

Abstract:

The effects of salvianolic acids (sal A) on hydroxylation of salicylic acid in EDTA- H2O2-Fe²⁺ and Vit C-H2O2-Fe²⁺ systems were studied. In the latter system, the compounds were shown to dose-dependently inhibit the hydroxylation of salicylic acid and the efficacy order was basically incorrespondence with that for anti-lipid-peroxidation. But in the former system, the effects weresomewhat complex, most of the compounds dose-dependently inhibited hydroxylation of salicylic acidexcept Sal A, which, like Vit C, promoted hydroxylation at lower concentration but inhibited it at higherconcentration. These compounds were found to chelate to or react with iron ions, but their apparentchelating constants were about 100 fold lower than that of EDTA. Salvianolic acids were thusconsidered to be hydroxyl radical scavengers.

Key words: Salvianolic acids, Hydroxyl radical, Salicylic acid hydroxylation, Apparent chelatingconstant, Iron ion

Supporting:

刘雨, 张均田. 丹参酚酸类对羟自由基的捕捉作用[J]. .

Yu Liu, Jun-Tian Zhang. Hyroxyl Radical Scavenging Effect of Salvianolic Acids[J]. .

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