泊洛沙姆和一些辅助剂的混合物对亚微乳剂稳定性的影响

泊洛沙姆和一些辅助剂的混合物对亚微乳剂稳定性的影响

郑俊民, 丁平田, 董世波

1. 沈阳药学院药剂学教研室, 沈阳 110015;
2. 山东新华制药厂, 淄博 255005;
3. 山东省医药工业研究所, 济南 250100

收稿日期:1992-12-30 修回日期:1993-08-23 出版日期:1994-06-15 发布日期:1994-06-15

Effect of Poloxamer and Adjuvants Admixture on Stability of Submicronized Emulsion

Jun-Min Zheng, Ping-Tian Ding, Shi-Bo Dong

1. Department of Pharmaceutics, Shenyang College of Pharmacy, Shenyang 110015;
2. Shandong Xinhua Pharmaceutical Factory, Zibo 255005;
3. Shandong Institute of Pharmaceutical Industry, Jinan 250100

Received:1992-12-30 Revised:1993-08-23 Online:1994-06-15 Published:1994-06-15

摘要/Abstract

摘要： 将一些辅助剂加在泊洛沙姆108中, 能对其昙点产生不同的影响。泊洛沙姆与改制的大豆磷脂混合物能提高该系统的昙点至125 ºC, 以此为乳化剂制成安定亚微乳剂, 通过粒度和动电位测定来考察其稳定性, 安定亚微乳剂平均粒度为67.1 nm。稳定常数为1.06。动电位为-27.15 mV, 比仅用泊洛沙姆为乳化剂制成的亚微乳剂的动电位为高。

关键词: 泊洛沙姆, 亚微乳剂, 昙点, 安定

Abstract: The addition of a number of adjuvants to Poloxamer 108 can diversely affect its cloud point. Poloxamer-modified soybean lecithin admixture (PSLA) can elevate the cloud point of the system to 125 ºC. The stabilizing effect on the diazepam submicronized emulsion (DSE) using PSLA as anemulsifying agent has been observed through particle size and zeta potential measurement. It was foundthat DSE had mean droplet size of 67.1 nm. The stability index was 1.06 and zeta potential was -27.15 mV, which was greater than that of DSE with the Poloxamer 108 as emulsifying agent only.

Key words: Poloxamer, Submicronized emulsion, Cloud point, Diazepam

Supporting:

郑俊民, 丁平田, 董世波. 泊洛沙姆和一些辅助剂的混合物对亚微乳剂稳定性的影响[J]. .

Jun-Min Zheng, Ping-Tian Ding, Shi-Bo Dong. Effect of Poloxamer and Adjuvants Admixture on Stability of Submicronized Emulsion[J]. .

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