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3-位含氮官能团取代的羊毛眼甾醇衍生物-甾醇24-甲基化转移酶抑制剂的合成

果德安, 胡军, 郑俊华, Samir A.Ross, W.David Nes

  

  1. 1. 北京医科大学药学院, 北京 100083;
    2. Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TA 79409, USA
  • 收稿日期:1996-12-26 修回日期:1997-05-15 出版日期:1997-09-15 发布日期:1997-09-15

Synthesis of 3-Nitrogen containing Function Substituted Lanosterol Derivatives-Inhibitors of (S)-Adenosyl-L-Me-thionine: Δ24(25)-Sterol Methyltransferase

De-An Guo, Jun Hu, Jun-Hua Zheng, Samir A.Ross, W.David Nes   

  1. 1. School of Pharmaceutical Sciences; Beijing Medical University; Beijing 100083;
    2. Department of Chemistry and Biochemistry; Texas Tech University; Lubbock 79409; USA
  • Received:1996-12-26 Revised:1997-05-15 Online:1997-09-15 Published:1997-09-15

摘要: 本文报道了羊毛甾醇3-, 3-乙酰羊毛甾醇, 3-羊毛甾醇, 3α-氨基羊毛甾醇和3β-氨基羊毛甾醇的合成方法。所合成的产物应用薄层色谱(Rf值), 气相色谱(RRTc值)和光谱学(红外, 质谱, 核磁共振氢谱和碳谱)等方法鉴定了它们的结构。

关键词: 生物合成, 抑制剂, 羊毛甾醇, 甾醇甲基化转移酶, 合成

Abstract: Syntheses of 3-ketolanosterol, 3-acetolanosterol, 3-oximolanosterol, 3α- and 3β-aminolanosterol were described The products have been fully characterized on the basis of their chromatographic (TLC Rf, GLC RRTc) and spectral (IR, MS, 1H NMR, 13C NMR) properties.

Key words: Biosynthesis, Inhibitor, Lanosterol, Sterol methyltransferase, Synthesis

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